Cholesterol-dependent control of plasma membrane lipid rafts

质膜脂筏的胆固醇依赖性控制

• 批准号: ARC : DP0212068
• 负责人: Dr Wendy Jessup
• 金额: $ 23.1万
• 依托单位: The Heart Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cholesterol-dependent-control-lipid-rafts/62256
• 关键词: Cholesterol; dependent; control; plasma; membrane

Cholesterol-dependent control of plasma membrane lipid rafts. Lipid rafts are recently discovered micro-domains in the plasma membrane that are highly enriched in cholesterol, giving these domains a unique lipid structure. Because of their distinct structure specific proteins partition into these domains so that lipid rafts act as message transduction centres in a variety of cell functions. It is hypothesised that cholesterol is the link between the distinct biophysical parameters of lipid rafts and their function. The aim of this proposal is to understand how cellular cholesterol levels contribute to raft structure and function, thus elevating cholesterol to a regulatory element for lipid raft and their function.

质膜脂筏的胆固醇依赖控制。脂筏是最近在质膜上发现的高度富含胆固醇的微域，使这些域具有独特的脂质结构。由于其独特的结构，特定的蛋白质被划分到这些区域中，因此脂筏在各种细胞功能中扮演着信息转导中心的角色。假设胆固醇是脂筏的不同生物物理参数与其功能之间的联系。这项建议的目的是了解细胞胆固醇水平如何影响脂筏的结构和功能，从而将胆固醇提升为脂筏的调节元件及其功能。