Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection.

粪抗原检测试验诊断肠道寄生线虫感染。该项目的目的是开发新的检测钩虫和类圆线虫的方法，这是两种常见的人类肠道蠕虫感染。这些测试提供了替代当前测试的潜力，即粪便显微镜检查和血清学诊断，由于灵敏度、特异性和操作者便利性方面的缺陷，这两种测试的性能都不令人满意。这些测试将依靠单克隆抗体来检测粪便中的寄生虫产物。这种测试技术适合于以稳健的形式配置，适合于大规模制造。鉴于这些寄生虫在世界范围内的流行，这些测试将具有国际意义的市场潜力。

Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.