Synthesis and Characterization of Transition-Metal Sulfide Fluorides, and Main-Group Fluorides and Oxide Fluorides

过渡金属硫化物氟化物、主族氟化物和氧化物氟化物的合成与表征

基本信息

  • 批准号:
    261340-2008
  • 负责人:
  • 金额:
    $ 2.55万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2010
  • 资助国家:
    加拿大
  • 起止时间:
    2010-01-01 至 2011-12-31
  • 项目状态:
    已结题

项目摘要

Fluorine is the most reactive element. Its reactivity makes possible to prepare small, structurally simple molecules that would be unstable without the presence of the element fluorine. Basic studies of molecular structures help chemists check the validity of theories; theories that are applied to a host of practical problems, from new materials to pharmaceuticals. The proposed research will involve the preparation of novel compounds that have sulfur and fluorine surrounding a central metal atom. These so-called sulfide fluorides are the starting point for the study of their reaction chemistry. Since sulfur complexes are found in biological systems, such as ferredoxins, the influence of fluorine on the nature of those sulfur complexes will be investigated. The potential use of sulfide fluorides is as catalysts in the petroleum industry. The combination of these sulfide fluorides with other metal cations is expected to result in larger aggregations. If it is possible to increase their size, these compounds could be used as materials. The utilization of sulfide fluorides as fluorination agents will be studied and may result in their use in the pharmaceutical industry to prepare fluorinated drugs, such as 5-fluorouracil as a drug against breast cancer and the antidepressants fluoxetine and paroxetine, which have been proven to possess remarkable potencies. These inorganic sulfide fluorides will be characterized, among other means, by NMR spectroscopy in the solid state. This characterization technique is still in its infancies for fluorine-containing compounds. The proposal pursues the extension of solid-state NMR spectroscopy to a large variety of inorganic fluorine compounds.
氟是最活泼的元素。它的反应性使得制备结构简单的小分子成为可能,如果没有氟元素的存在,这些分子将是不稳定的。对分子结构的基础研究有助于化学家检验理论的有效性;这些理论适用于从新材料到药物的许多实际问题。拟议的研究将涉及制备中心金属原子周围含有硫和氟的新型化合物。这些所谓的硫化物氟化物是研究其反应化学的起点。由于在生物系统中发现了硫络合物,如铁氧化还原蛋白,因此将研究氟对这些硫络合物性质的影响。硫化物氟化物的潜在用途是作为石油工业中的催化剂。这些硫化物氟化物与其他金属阳离子的组合预计会导致更大的聚集体。如果有可能增加它们的尺寸,这些化合物可以用作材料。将研究硫化物氟化物作为氟化剂的利用,并可能导致它们在制药工业中用于制备氟化药物,例如作为抗乳腺癌药物的5-氟尿嘧啶和抗抑郁药氟西汀和帕罗西汀,这些药物已被证明具有显着的效力。这些无机硫化物氟化物将通过固体状态下的NMR光谱法等手段进行表征。这种表征技术对含氟化合物的研究尚处于起步阶段。该提案旨在将固态NMR光谱扩展到各种无机氟化合物。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Gerken, Michael其他文献

Characteristics and outcome of patients with small bowel adenocarcinoma (SBA).
  • DOI:
    10.1007/s00432-022-04344-z
  • 发表时间:
    2023-07
  • 期刊:
  • 影响因子:
    3.6
  • 作者:
    Teufel, Andreas;Meindl-Beinker, Nadja M.;Hosel, Pauline;Gerken, Michael;Roig, Ana;Ebert, Matthias P.;Herr, Wolfgang;Scheiter, Alexander;Pauer, Armin;Schlitt, Hans J.;Klinkhammer-Schalke, Monika
  • 通讯作者:
    Klinkhammer-Schalke, Monika
Single-institution cross-sectional study to evaluate need for information and need for referral to psychooncology care in association with depression in brain tumor patients and their family caregivers
  • DOI:
    10.1186/s40359-020-00460-y
  • 发表时间:
    2020-09-10
  • 期刊:
  • 影响因子:
    3.6
  • 作者:
    Reinert, Christiane;Gerken, Michael;Hau, Peter
  • 通讯作者:
    Hau, Peter
Quality management in oncology supported by clinical cancer registries
Statin Use Ameliorates Survival in Oral Squamous Cell Carcinoma-Data from a Population-Based Cohort Study Applying Propensity Score Matching.
  • DOI:
    10.3390/biomedicines11020369
  • 发表时间:
    2023-01-27
  • 期刊:
  • 影响因子:
    4.7
  • 作者:
    Spoerl, Steffen;Gerken, Michael;Fischer, Rene;Spoerl, Silvia;Kirschneck, Christian;Wolf, Stefanie;Taxis, Juergen;Ludwig, Nils;Biermann, Niklas;Reichert, Torsten E.;Spanier, Gerrit
  • 通讯作者:
    Spanier, Gerrit
Treatment of Colorectal Cancer in Certified Centers: Results of a Large German Registry Study Focusing on Long-Term Survival.
  • DOI:
    10.3390/cancers15184568
  • 发表时间:
    2023-09-15
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Voelkel, Vinzenz;Gerken, Michael;Kleihues-van Tol, Kees;Schoffer, Olaf;Bierbaum, Veronika;Bobeth, Christoph;Roessler, Martin;Reissfelder, Christoph;Fuerst, Alois;Benz, Stefan;Rau, Bettina M.;Piso, Pompiliu;Distler, Marius;Guenster, Christian;Hansinger, Judith;Schmitt, Jochen;Klinkhammer-Schalke, Monika
  • 通讯作者:
    Klinkhammer-Schalke, Monika

Gerken, Michael的其他文献

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{{ truncateString('Gerken, Michael', 18)}}的其他基金

Donor-Stabilized Fluorido Cations and New Tungsten-Based Weakly Coordinating Anions
供体稳定的氟阳离子和新型钨基弱配位阴离子
  • 批准号:
    RGPIN-2022-03698
  • 财政年份:
    2022
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Sulfur in Inorganic Fluorine Chemistry and the Development of a New Class of Weakly Coordinating Anions
无机氟化学中的硫和一类新型弱配位阴离子的开发
  • 批准号:
    261340-2013
  • 财政年份:
    2021
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Sulfur in Inorganic Fluorine Chemistry and the Development of a New Class of Weakly Coordinating Anions
无机氟化学中的硫和一类新型弱配位阴离子的开发
  • 批准号:
    261340-2013
  • 财政年份:
    2020
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Sulfur in Inorganic Fluorine Chemistry and the Development of a New Class of Weakly Coordinating Anions
无机氟化学中的硫和一类新型弱配位阴离子的开发
  • 批准号:
    261340-2013
  • 财政年份:
    2019
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Sulfur in Inorganic Fluorine Chemistry and the Development of a New Class of Weakly Coordinating Anions
无机氟化学中的硫和一类新型弱配位阴离子的开发
  • 批准号:
    261340-2013
  • 财政年份:
    2018
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Sulfur in Inorganic Fluorine Chemistry and the Development of a New Class of Weakly Coordinating Anions
无机氟化学中的硫和一类新型弱配位阴离子的开发
  • 批准号:
    261340-2013
  • 财政年份:
    2017
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Sulfur in Inorganic Fluorine Chemistry and the Development of a New Class of Weakly Coordinating Anions
无机氟化学中的硫和一类新型弱配位阴离子的开发
  • 批准号:
    261340-2013
  • 财政年份:
    2016
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Sulfur in Inorganic Fluorine Chemistry and the Development of a New Class of Weakly Coordinating Anions
无机氟化学中的硫和一类新型弱配位阴离子的开发
  • 批准号:
    261340-2013
  • 财政年份:
    2015
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Sulfur in Inorganic Fluorine Chemistry and the Development of a New Class of Weakly Coordinating Anions
无机氟化学中的硫和一类新型弱配位阴离子的开发
  • 批准号:
    261340-2013
  • 财政年份:
    2014
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual
Sulfur in Inorganic Fluorine Chemistry and the Development of a New Class of Weakly Coordinating Anions
无机氟化学中的硫和一类新型弱配位阴离子的开发
  • 批准号:
    261340-2013
  • 财政年份:
    2013
  • 资助金额:
    $ 2.55万
  • 项目类别:
    Discovery Grants Program - Individual

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具有异常键合和物理性质的过渡金属和主族配合物的合成与表征
  • 批准号:
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过渡金属硫化物氟化物、主族氟化物和氧化物氟化物的合成与表征
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    261340-2008
  • 财政年份:
    2012
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  • 项目类别:
    Discovery Grants Program - Individual
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过渡金属硫化物氟化物、主族氟化物和氧化物氟化物的合成与表征
  • 批准号:
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过渡金属硫化物氟化物、主族氟化物和氧化物氟化物的合成与表征
  • 批准号:
    261340-2008
  • 财政年份:
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    $ 2.55万
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    Discovery Grants Program - Individual
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亚稳态过渡金属氧化物和氮氧化物的合成、表征和理论描述
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