Molecular diversity from naphthalene nucleus

萘核的分子多样性

• 批准号: 261684-2010
• 负责人: Jha, Amitabh
• 金额: $ 2.19万
• 依托单位: Acadia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=456059
• 关键词: Molecular; diversity; naphthalene; nucleus

All aspects of applied organic chemistry rely on the ability to generate a vast variety of novel molecular architectures with interesting properties. This places a persistent demand on the synthetic organic chemists to develop and fine-tune various procedures that enable the synthesis of the desired structural frameworks. The research laboratory of the applicant has actively been involved in the synthesis of novel molecular frameworks from naphthalene nucleus over the past several years. Building on this evolving expertise, the applicant plans to continue devising practical synthetic routes to construct an array of important novel molecular frameworks, from naphthalene core, having a variety of molecular topology and functional groups. The putative synthetic designs will lead to synthesis of a selection of quasi-steroids and novel naphthalene-based oxacycles in addition to the development of several practical synthetic methodologies for important organic transformations. Asymmetric synthesis will be undertaken employing chiral induction through catalysis. The specific target skeletons selected for this investigation are expected to possess a wide variety of topologies and properties. Wherever possible studies will be undertaken to unravel any interesting spectroscopic and electronic properties of the molecules synthesized. Attempts will also be made to make the library of compounds synthesized available to fellow scientists with complementary expertise to study their potential as pharmaceuticals, catalysts, photocages, fluorophores, etc. During the tenure of this grant, ~8 graduate students and ~20 advanced undergraduate students will receive high quality training in the art of organic synthesis and scientific writing among other research related skills. In addition to imparting intensive HQP training, this endeavor will lead to new knowledge in the field of methodology development in general and in the area of quasi-steroid and o-naphthoquinone methide generation and application in particular. The medicinal chemistry community working on the development of quasi-steroidal drugs (and ultimately human health) will benefit from the outcome of the proposed research.

应用有机化学的所有方面都依赖于产生具有有趣特性的各种新型分子体系结构的能力。这对合成有机化学家的持续需求持续开发和调整各种程序，以使所需的结构框架合成。在过去的几年中，申请人的研究实验室积极参与了萘核的新分子框架的合成。申请人在这种不断发展的专业知识的基础上，计划继续设计实用的合成路线，以构建来自萘核心的一系列重要的新型分子框架，这些核心具有各种分子拓扑和官能团。推定的合成设计还将导致合成一系列准类固醇和新型的基于萘的牛仔环，除了开发用于重要有机转化的几种实际合成方法。通过催化，将采用手性诱导进行不对称合成。预计为此研究选择的特定目标骨骼将具有多种拓扑和特性。在可能的情况下，将进行研究以揭示合成的分子的任何有趣的光谱和电子特性。还将尝试使具有补充专业知识的科学家合成化合物图书馆，以研究其作为药品，催化剂，光电，荧光团等的潜力。在这项拨款期间，约8名研究生和约20名高级本科生将获得有机综合和其他研究相关的研究艺术的高质量培训。除了进行密集的HQP培训外，这项努力还将导致一般方法论发展领域以及准甾体类和O-萘醌甲基甲基甲酯的产生和应用领域的新知识。致力于开发准甾体类药物（以及最终人类健康）的药物化学界将受益于拟议研究的结果。