Molecular diversity from naphthalene nucleus

萘核的分子多样性

• 批准号: 261684-2010
• 负责人: Jha, Amitabh
• 金额: $ 2.19万
• 依托单位: Acadia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=479951
• 关键词: Molecular; diversity; naphthalene; nucleus

All aspects of applied organic chemistry rely on the ability to generate a vast variety of novel molecular architectures with interesting properties. This places a persistent demand on the synthetic organic chemists to develop and fine-tune various procedures that enable the synthesis of the desired structural frameworks. The research laboratory of the applicant has actively been involved in the synthesis of novel molecular frameworks from naphthalene nucleus over the past several years. Building on this evolving expertise, the applicant plans to continue devising practical synthetic routes to construct an array of important novel molecular frameworks, from naphthalene core, having a variety of molecular topology and functional groups. The putative synthetic designs will lead to synthesis of a selection of quasi-steroids and novel naphthalene-based oxacycles in addition to the development of several practical synthetic methodologies for important organic transformations. Asymmetric synthesis will be undertaken employing chiral induction through catalysis. The specific target skeletons selected for this investigation are expected to possess a wide variety of topologies and properties. Wherever possible studies will be undertaken to unravel any interesting spectroscopic and electronic properties of the molecules synthesized. Attempts will also be made to make the library of compounds synthesized available to fellow scientists with complementary expertise to study their potential as pharmaceuticals, catalysts, photocages, fluorophores, etc. During the tenure of this grant, ~8 graduate students and ~20 advanced undergraduate students will receive high quality training in the art of organic synthesis and scientific writing among other research related skills. In addition to imparting intensive HQP training, this endeavor will lead to new knowledge in the field of methodology development in general and in the area of quasi-steroid and o-naphthoquinone methide generation and application in particular. The medicinal chemistry community working on the development of quasi-steroidal drugs (and ultimately human health) will benefit from the outcome of the proposed research.

应用有机化学的所有方面都依赖于产生具有有趣性质的各种新型分子结构的能力。这对合成有机化学家提出了持续的要求，以开发和微调各种程序，从而能够合成所需的结构框架。在过去的几年里，申请人的研究实验室积极参与了由萘核合成新型分子框架的工作。基于这种不断发展的专业知识，申请人计划继续设计实用的合成路线，以从萘核构建一系列重要的新型分子框架，具有各种分子拓扑结构和官能团。推定的合成设计将导致合成选择的准甾体和新的萘基氧杂环化合物，除了几个实用的合成方法的发展，重要的有机转化。不对称合成将通过催化采用手性诱导进行。为本次调查选择的特定目标骨架预计将拥有各种各样的拓扑结构和属性。只要有可能，将进行研究，以揭示合成分子的任何有趣的光谱和电子特性。还将努力使图书馆的化合物合成提供给同行的科学家与互补的专业知识，以研究其作为药物，催化剂，photocages，荧光团等的潜力，在此期间授予任期内，约8名研究生和约20名高级本科生将接受高质量的培训，在有机合成和科学写作等研究相关技能的艺术。除了给予密集的HQP培训，这一奋进将导致在一般的方法学发展领域，特别是在准类固醇和邻萘醌甲基化物的产生和应用领域的新知识。致力于开发准甾体药物（最终是人类健康）的药物化学界将受益于拟议研究的结果。