The role of Plk4 in the centrosome, the DNA damage response and development

Plk4在中心体中的作用、DNA损伤反应和发育

• 批准号: 298476-2010
• 负责人: Hudson, John
• 金额: $ 1.97万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=456910
• 关键词: role; Plk4; centrosome; DNA; damage

The major focus of my research is to study the function of the protein Plk4 (also known as Sak). Plk4 belongs to a family of proteins that modify the structure of other proteins and hence regulate their activity, function and stability. Plk4 is typically found in dividing mammalian cells and is involved in the regulation of this process. In the past we have generated a Plk4 mutant mouse strain; in these mice the DNA sequence encoding for Plk4 protein has been replaced with a completely different sequence on one allele (normally, there are two alleles for

我研究的主要重点是研究蛋白Plk 4（也称为Sak）的功能。Plk 4属于修饰其他蛋白质结构并因此调节其活性、功能和稳定性的蛋白质家族。Plk 4通常存在于分裂的哺乳动物细胞中，并参与该过程的调节。在过去，我们已经产生了Plk 4突变小鼠品系;在这些小鼠中，编码Plk 4蛋白的DNA序列已经被一个等位基因上的完全不同的序列所取代（通常，编码Plk 4蛋白的DNA序列有两个等位基因）。