The multifaceted roles of PLK4

PLK4 的多方面作用

• 批准号: RGPIN-2015-05947
• 负责人: Hudson, John
• 金额: $ 2.19万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590740
• 关键词: multifaceted; roles; PLK4

Years of carefully planned and carried out experiments has determined that the protein called Polo like kinase 4 (PLK4), is a major regulator of centrosome duplication. Centrosomes are small organelles, which are involved in ensuring that the genetic information in cells is passed on equally when a cell divides. PLK4 is a member of a group of proteins known as kinases. These proteins modify the structure and thereby the function or activity of proteins that they interact with. We and others have focused on establishing that alterations of PLK4 levels, either due to an increase or a decrease, have a detrimental effect on cells. PLK4 plays an important role during development, as mouse lacking one allele of

多年来精心计划和进行的实验已经确定，称为波罗样激酶4（PLK 4）的蛋白质是中心体复制的主要调节因子。中心体是一种小的细胞器，当细胞分裂时，它参与确保细胞中的遗传信息平等地传递。PLK4是一组称为激酶的蛋白质的成员。这些蛋白质改变结构，从而改变与它们相互作用的蛋白质的功能或活性。我们和其他人一直致力于确定PLK4水平的改变，无论是由于增加还是减少，都对细胞产生不利影响。PLK4在发育过程中起着重要作用，因为小鼠缺乏一个PLK4等位基因，