Role of tuberin in mitotic progression

分裂成两个子细胞是许多细胞群体一生中发生的一个事件，包括DNA的成功复制，随后是细胞分裂或细胞质分裂。至关重要的是，这些事件以正确的顺序发生，没有错误，并且细胞在形成新的子细胞期间监测其大小和能量需求。这些事件的协调和监测依赖于称为细胞周期蛋白的调节蛋白和称为细胞周期蛋白依赖性激酶（CDK）的催化蛋白家族。细胞周期蛋白和CDK蛋白形成一个复合体，反过来触发细胞通过细胞生长和分裂的这些阶段所需的所有事件。这些重要复合物的形成和激活依赖于多层调控，其中许多仍有待解决。本研究计划的重点是确定这些复合物如何被调节以启动细胞分裂的开始。重要的是，我们的实验室有令人兴奋的数据，将已知的监测营养和生长因子含量与细胞分裂的蛋白质联系起来。我们认为这一数据反映了一种新的检查点，它对维持适当的生长控制至关重要。

Division into two daughter cells is an event that occurs throughout life in many cell populations and involves the successful duplication of the DNA followed by cell division or cytokinesis. It is essential that these events occur in the correct order, without error and that the cell monitors its size and energy requirements during the formation of a new daughter cell. Coordination and monitoring over these events depends on regulatory proteins called cyclins and a family of catalytic proteins called the cyclin dependent kinases (CDK)s. Cyclin and CDK proteins form a complex that in turn trigger all of the events required to move the cell through these phases of cell growth and division. Formation and activation of these important complexes relies on many layers of regulation, much of which still remains to be resolved. This research program focuses on determining how these complexes are regulated to initiate the onset of cell division. Importantly, our lab has exciting data linking proteins known to monitor nutrient and growth factor content with cell division. We propose that this data reflects a novel checkpoint which is essential for maintaining proper growth control.