Discovery Projects - Grant ID: DP210100614

发现项目 - 拨款 ID：DP210100614

• 批准号: ARC : DP210100614
• 负责人: Azim Surani
• 金额: $ 46.65万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discovery-projects-grant-id-dp210100614/1782834
• 关键词: Discovery; Projects; Grant; ID; DP210100614

Mobile DNA activity in the mammalian primordial germline. Early in pregnancy, a handful of cells in the embryo become primordial germ cells (PGCs). These PGCs will eventually give rise to sperm or egg cells, representing a critical inter-generational genetic link. Mobile DNA sequences target PGCs to create new heritable genetic changes. This proposal aims to analyse the activity, regulation, and consequences of mobile DNA activity in PGCs. This project expects to generate significant knowledge about the origins of mammalian genetic diversity. Expected outcomes include enhanced national and international collaborations across disciplines and new experimental systems. The expected benefit is an enhanced understanding of the mutational processes underlying genetic diversity and disease in mammals.

哺乳动物原始生殖系中移动的DNA活性。在怀孕早期，胚胎中的少数细胞成为原始生殖细胞（PGCs）。这些原始生殖细胞最终将产生精子或卵细胞，代表着一种关键的代际遗传联系。移动的DNA序列靶向PGCs以产生新的可遗传的遗传变化。该建议旨在分析PGCs中移动的DNA活性的活性、调节和后果。该项目预计将产生有关哺乳动物遗传多样性起源的重要知识。预期成果包括加强跨学科的国家和国际合作以及新的实验系统。预期的好处是提高对哺乳动物遗传多样性和疾病背后的突变过程的理解。