Restoration of joint function through subchodral delivery of therapeutics

通过软骨下给药恢复关节功能

• 批准号: 365025-2008
• 负责人: Hoemann, Caroline
• 金额: $ 10.81万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=460881
• 关键词: Restoration; joint; function; through; subchodral

The knee is a complex organ that depends on healthy cartilage for pain-free articulation and proper joint function. Damaged cartilage can lead to joint pain and stiffness, loss of quality of life, and eventually lead a patient to seek clinical help. To re-grow cartilage over areas of exposed bone, many surgeons use an arthroscopic technique called microfracture to induce bleeding from the base of the cartilage lesion and stimulate a natural cartilage-repair response. When successful, these so-called "resurfacing" procedures can re-stabilize the joint and slow the progression of osteoarthritis. To improve the current standard of care, we have developed therapeutic implants which are made of patient whole blood mixed with chitosan, a biopolymer that contains glucosamine. Our research has shown that chitosan helps repair damaged bone and cartilage by

膝关节是一个复杂的器官，它依赖于健康的软骨来实现无痛的关节连接和适当的关节功能。软骨受损会导致关节疼痛和僵硬，生活质量下降，最终导致患者寻求临床帮助。为了在暴露的骨区域重新生长软骨，许多外科医生使用称为微骨折的关节镜技术，以诱导软骨病变基底出血并刺激自然的软骨修复反应。当成功时，这些所谓的“表面重塑”程序可以重新稳定关节并减缓骨关节炎的进展。为了提高当前的护理标准，我们开发了治疗植入物，该植入物由患者全血与壳聚糖（一种含有葡萄糖胺的生物聚合物）混合制成。我们的研究表明，壳聚糖有助于修复受损的骨骼和软骨，