Protein-polysaccharide biomaterial complexes: characterization and innate immune responses

蛋白质-多糖生物材料复合物：表征和先天免疫反应

• 批准号: 262874-2009
• 负责人: Hoemann, Caroline
• 金额: $ 1.46万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525581
• 关键词: Protein; polysaccharide; biomaterial; complexes; characterization

Tissue engineering is intended to replace damaged organs, and invariably requires the regeneration of lost blood vessels. We have discovered a new avenue for regenerating blood vessels, by implanting biodegradable polymers that stimulate the innate immune system to release angiogenic factors. Phagocytes are innate immune cells that circulate in our blood stream, whose role is to recognize and eliminate bacteria and foreign materials. Sometimes when phagocytes are activated, they release factors that stimulate growth of new blood vessels. More research is needed to understand how implanted biomaterials can be used to stimulate a predictable angiogenic response by innate immune cells. All biodegradable materials, after coming into contact with body fluids, acquire a coating of proteins and other factors that can have therapeutic or pathological consequences. The aim of our research program is to further our understanding of how the immune system recognizes and responds to biomaterials of different charge state and solubility. To accomplish our goal we need to better understand how biomaterial structure influences "biofouling" of the polymer surface with plasma proteins and other blood factors. Results from this research program will result in the development of novel medical devices that offer a more predictable and optimal therapeutic effect.

组织工程的目的是替换受损的器官，并且总是需要再生失去的血管。我们发现了一条再生血管的新途径，通过植入可生物降解的聚合物来刺激先天免疫系统释放血管生成因子。吞噬细胞是在我们血液中循环的先天免疫细胞，其作用是识别和清除细菌和外来物质。有时当吞噬细胞被激活时，它们会释放刺激新血管生长的因子。需要更多的研究来了解植入的生物材料如何被用来刺激先天免疫细胞可预测的血管生成反应。所有可生物降解的材料在与体液接触后，都会获得一层蛋白质和其他可能具有治疗或病理后果的因素。我们研究计划的目的是进一步了解免疫系统如何识别和响应不同电荷状态和溶解度的生物材料。为了实现我们的目标，我们需要更好地了解生物材料结构如何影响聚合物表面与血浆蛋白和其他血液因子的“生物污垢”。这项研究计划的结果将导致新型医疗设备的发展，提供更可预测和最佳的治疗效果。