Cryogenic module for biomedical and biotechnology infrastructure

我们的多学科生物医学研究团队使用培养细胞开发安全有效的治疗方法来再生受损组织，如软骨。我们也在创造新的基因传递方法来治疗慢性疾病。要做到这一点，我们需要更多地了解细胞如何识别和反应生物材料，以及如何最佳地诱导细胞表达外源基因。我们的研究项目使用的细胞来自同意的人类志愿者，以及在培养中不断分裂的细胞系。多年来，我们已经开发了大量有价值的细胞库，这些细胞库在探索细胞对生物材料和纳米颗粒的复杂反应以及如何引导细胞释放大量治疗性蛋白质方面非常有用。我们也在生物医学工程教学项目中使用细胞。由于细胞是周期性使用的，我们大量的细胞系、克隆和原代细胞需要一种敏感和可控的系统来将这些细胞保存在一个稳定的冷冻状态下，即冷冻保存。目前我们小组缺乏冷冻和储存大量细胞库存所需的设备。这项拨款申请是为了给我们的实验室配备冷冻保存设备，以便我们能够保存和保存对开发新疗法有用的细胞。

Our multidisciplinary biomedical research team uses cultured cells to develop safe and effective therapies to regenerate damaged tissues such as cartilage. We are also creating novel gene delivery methods for treating chronic diseases. To do this, we need to know more about how cells recognize and react to biomaterials, and how cells can be optimally induced to express foreign genes. Our research program uses cells obtained from consented human volunteers, and cell lines that continually divide in culture. Over the years we have developed a large and valuable repertoire of cell stocks that are very useful in exploring the complex reactions of cells to biomaterials and nanoparticles, and how cells can be led to release vast quantities of therapeutic proteins. We also use cells in our biomedical engineering teaching program. Because cells are used on a periodic basis, our vast repertoire of cell lines, clones, and primary cells require a sensitive and controlled system to preserve the stocks in a stable frozen state known as cryopreservation. Currently our group is lacking equipment needed to freeze and store a large number of cell stocks. This grant application is a request for funds to equip our laboratories with cryopreservation equipment so that we can maintain and preserve cells useful for developing new treatments.