Using reconsolidation to understand the structure and molecular underpinning of memory - Steacie Supplement

使用重新巩固来理解记忆的结构和分子基础 - Steacie Supplement

• 批准号: 373515-2009
• 负责人: Nader, Karim
• 金额: $ 16.25万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: EWR Steacie Fellowships - Supplement
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=461808
• 关键词: Using; reconsolidation; understand; structure; molecular

One of the greatest capacities our brains possess is the ability to store memories that can last a lifetime. Memory consolidation theory posits that new memories initially enter a labile state called short term memory (STM) and through the production of new proteins can be transformed into long term memories (LTM). This process is posited to take place only once for each memory. Recently I have shown that following retrieval, consolidated memories require new proteins synthesis in a brain structure called the amygdala in order for them to persist. In other words, the mechanisms involved in the storage of new memories seem to be recapitulated when old memories are reactivated. This phenomenon is called reconsolidation.

我们的大脑拥有的最伟大的能力之一就是储存可以持续一生的记忆的能力。记忆巩固理论认为，新的记忆最初进入一种称为短期记忆（STM）的不稳定状态，通过产生新的蛋白质可以转化为长期记忆（LTM）。此过程假定每个内存只发生一次。最近我已经证明，在检索之后，巩固的记忆需要在一个叫做杏仁核的大脑结构中合成新的蛋白质，以使它们持续存在。换句话说，当旧记忆被重新激活时，涉及新记忆存储的机制似乎也会重演。这种现象被称为再巩固。