Analysis of evolutionary mechanisms in signaling networks

信号网络进化机制分析

• 批准号: 386671-2010
• 负责人: Kim, Philip
• 金额: $ 1.68万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=463898
• 关键词: Analysis; evolutionary; mechanisms; signaling; networks

We have witnessed the rise of a new paradigm in bioscience, which put biological networks in the focus of scientific study. Of particular importance are signaling networks as the "CPU" of cells. These signaling pathways tightly regulate cellular processes and are finely tuned to respond to external stimuli. The rise of increasingly sophisticated signaling networks in our evolutionary history enabled the increasing complexity of higher organisms. How these networks arose in our evolutionary history has thus far not undergone rigorous study and the mechanisms at play are unknown. However, it is clear that signaling networks have been adapting to different evolutionary pressures and have undergone extensive rewiring, thereby enabling evolutionary progress.

我们见证了生物科学中一种新范式的兴起，它将生物网络置于科学研究的中心。特别重要的是信令网络作为细胞的“中央处理器”。这些信号通路严格调控细胞过程，并微调以对外部刺激做出反应。在我们的进化史上，日益复杂的信号网络的出现使得高等生物体的复杂性不断增加。到目前为止，这些网络是如何在我们的进化史中出现的，还没有经过严格的研究，其作用机制也是未知的。然而，很明显，信令网络一直在适应不同的进化压力，并经历了广泛的重新布线，从而使进化成为可能。