Identification and characterisation of caspase inhibitors.

Caspase 抑制剂的鉴定和表征。

• 批准号: ARC : DP0208537
• 负责人: Dr Christine Hawkins
• 金额: $ 15.6万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-characterisation-caspase-inhibitors/71193
• 关键词: Identification; characterisation; caspase; inhibitors.

Identification and characterisation of caspase inhibitors. Organisms use a tightly controlled process of cell death (termed apoptosis) to remove dangerous and unwanted cells. Dysregulation of this process can contribute to diseases such as cancer and autoimmune disease. Caspases are protease effectors of apoptosis. Regulation of their activity is vital for effective control of cell survival and death. Using a functional screening system invented by the 1st CI, we aim to isolate and characterise novel inhibitors of caspases. Such inhibitors may in time be used as targets for development of therapeutic or diagnostic reagents aimed at manipulating the apoptotic process to diagnose, prevent or treat disease.

半胱天冬酶抑制剂的鉴定和表征。生物体使用严格控制的细胞死亡过程（称为凋亡）来去除危险和不需要的细胞。这一过程的失调可能导致癌症和自身免疫性疾病等疾病。半胱天冬酶是细胞凋亡的蛋白酶效应子。调节它们的活性对于有效控制细胞存活和死亡至关重要。利用第一代CI发明的功能筛选系统，我们的目标是分离和鉴定新型半胱天冬酶抑制剂。此类抑制剂可及时用作开发治疗或诊断试剂的靶标，所述治疗或诊断试剂旨在操纵细胞凋亡过程以诊断、预防或治疗疾病。