ARC Future Fellowships - Grant ID: FT210100271

ARC 未来奖学金 - 拨款 ID：FT210100271

• 批准号: ARC : FT210100271
• 金额: $ 93.57万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/arc-future-fellowships-id-ft210100271/1781679
• 关键词: ARC; Future; Fellowships; Grant; ID

Multi-functional probes for global analysis of proteome stress in cells. This project aims to create a suite of multi-functional chemical probes to identify damaged proteins that undergo unfolding or specific modifications in cells under stress. These probes will not only generate fluorescence responses to reflect on protein quality control capacity but allow associated proteins and their networks to be identified in complex cellular environments, which is difficult to achieve by current methods. The expected outcome is to deliver new methodology for a comprehensive understanding of the correlation between quality control machinery, stress responses and cell functions. This should provide significant benefits, including contributing to fundamental knowledge on the molecular causes of neurodegenerative diseases.

用于细胞蛋白质组应激整体分析的多功能探针。该项目旨在创建一套多功能化学探针，以识别在压力下细胞经历展开或特定修改的受损蛋白质。这些探针不仅会产生荧光反应来反映蛋白质的质量控制能力，而且还可以在复杂的细胞环境中识别相关的蛋白质及其网络，这是目前的方法难以实现的。预期的结果是提供新的方法，全面了解质量控制机制、应激反应和细胞功能之间的相关性。这应该会带来显著的好处，包括有助于了解神经退行性疾病的分子原因。