ARC Future Fellowships - Grant ID: FT210100455

照亮深色的中性粒细胞糖蛋白质组。该项目旨在阐明中性粒细胞白色血细胞的高度复杂和动态的糖包被表面，对我们先天免疫系统的细胞通讯和功能至关重要。该项目希望通过使用系统糖生物学方法详细描述这些细胞表面糖在不同中性粒细胞生命阶段的结构，形成，调节，相互作用和功能，从而产生对中性粒细胞生物学的分子水平见解。该项目将绘制中性粒细胞上和中性粒细胞中广泛的糖重塑，并揭示控制关键免疫过程的新的糖介导机制。该项目将通过扩大我们对支撑先天免疫系统的基本过程的了解来造福社区。

Illuminating the dark neutrophil glycoproteome. This project aims to shed light on the highly complex and dynamic sugar-coated surfaces of neutrophil white blood cells critical for the cell communication and function of our innate immune system. The project expects to generate molecular-level insights into neutrophil biology by detailing the structure, formation, regulation, interactions and functions of these cell-surface sugars across the varied neutrophil life stages using systems glycobiology approaches. The project will map the extensive sugar remodelling on and in the neutrophil and reveal new sugar-mediated mechanisms governing key immune processes. This project will benefit the community by expanding our knowledge of fundamental processes underpinning our innate immune system.