Development of a Lab-on-a-Chip Device for detection of Listeria in food samples

开发用于检测食品样品中李斯特菌的芯片实验室设备

• 批准号: 395014-2009
• 负责人: Mitra, SushantaKumar
• 金额: $ 2.19万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=467039
• 关键词: Development; Lab; Chip; Device; detection

Food safety is of paramount importance to Canada. Recent episode of Listeria out-break in a meat processing plant has created renewed interest in monitoring of food borne pathogens in ready-to-eat (RTE) meat products. The proposed device is aimed to detect Listeria monocytogenes in food samples within a few hours. This device integrates the microfluidics and the biosensor within a single platform, commonly referred to as a Lab-on-a-Chip (LOC). The proposed LOC will have a label free detection mechanism incorporating the state-of-art optofluidics principles and fabrications. The project will involve design, analysis and fabrication of the LOC and the prototype will be tested for its sensitivity and specificity towards L. monocytogenes. It is expected that the proposed LOC will provide timely early warning to any possible Listeria out-breaks in RTE meat products and will be an important tool for the regulators, like Canadian Food Inspection Agency, to monitor the meat processing units

食品安全对加拿大来说至关重要。最近在肉类加工厂发生的李斯特菌爆发事件重新引起了人们对即食（RTE）肉制品中食源性病原体监测的兴趣。拟议的仪器旨在在数小时内检测食物样本中的单核细胞增生李斯特菌。该设备将微流体和生物传感器集成在单个平台内，通常称为芯片实验室（Lab-on-a-Chip，简称PLD）。拟议的生物传感器将有一个无标记的检测机制，结合了最先进的光流体原理和制造。该项目将涉及设计，分析和制造的生物传感器和原型将测试其灵敏度和特异性对L。单核细胞增多症我们预期拟议的检验系统可就即食肉制品可能出现李斯特菌爆发的情况提供适时的预警，并会成为监管机构（例如加拿大食品检验局）监察肉类加工单位的重要工具