Mechanistic basis of a reproductive lesion in transforming growth factor beta-1 (TGFb1) null mutant mice

转化生长因子β-1（TGFb1）无效突变小鼠生殖损伤的机制基础

• 批准号: ARC : DP0211497
• 负责人: Dr Sarah Robertson
• 金额: $ 27.6万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanistic-basis-reproductive-mutant-mice/70782
• 关键词: Mechanistic; basis; reproductive; lesion; transforming

Mechanistic basis of a reproductive lesion in transforming growth factor beta-1 (TGFb1) null mutant mice. Null mutation in the gene encoding the cytokine transforming growth factor beta-1 (TGFb1) causes infertility in male and female mice. In recent experiments we have found that TGFb1 deficiency is associated with impaired ovarian and testicular steroidogenesis, arrested development of pre-implantation embryos and disrupted mammary gland morphogenesis. The aims of the current project are to unravel the mechanistic basis of the reproductive lesion in TGFb1 null mutant mice and to determine the effect of exogenous systemic delivery of TGFb1 in alleviating this lesion. It is expected that the project will provide new insight into key roles for TGFb1 in governing male and female fertility, and shed light on the prospects for exogenous supplementation of TGFb1 for improving reproductive performance in wild-type animals. This knowledge has potentially important applications in the livestock breeding industry, in devising novel contraceptive vaccine strategies, in the human pharmaceutical industry, and in devising novel contraceptive vaccine strategies.

转化生长因子β 1（TGF β 1）无效突变小鼠生殖损伤的机制基础。编码细胞因子转化生长因子β 1（TGF β 1）的基因突变导致雄性和雌性小鼠不育。在最近的实验中，我们发现TGF β 1缺乏与卵巢和睾丸类固醇合成受损，着床前胚胎发育停滞和乳腺形态发生中断有关。本项目的目的是阐明TGF β 1无效突变小鼠生殖损伤的机制基础，并确定外源性全身递送TGF β 1在减轻这种损伤中的作用。预计该项目将为TGFb1在管理男性和女性生育力方面的关键作用提供新的见解，并阐明外源性补充TGFb1以改善野生型动物生殖性能的前景。这些知识在畜牧业、设计新型避孕疫苗策略、人类制药业和设计新型避孕疫苗策略中具有潜在的重要应用。