Molecular and antibody analysis of cytomegalovirus (CMV) infection of fetal and placental cells

胎儿和胎盘细胞巨细胞病毒 (CMV) 感染的分子和抗体分析

• 批准号: ARC : LP0211586
• 负责人: A/Prof William Rawlinson
• 金额: $ 13.77万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-antibody-analysis-placental-cells/64438
• 关键词: Molecular; antibody; analysis; cytomegalovirus; CMV

Molecular and antibody analysis of cytomegalovirus (CMV) infection of fetal and placental cells. CMV is a beta herpesvirus with many unknown molecular mechanisms associated with cellular infection. The virus infects placental cells in vivo, although pathogenesis of viral damage to these cells has been extremely difficult to study in vitro. We have commenced a study to i) demonstrate the molecular accompaniments of infection of placental cells in vitro, ii) determine the genotypic characteristics of congenital CMV infections, in collaboration with Abbott Diagnostics, and iii) produce an in vivo model of CMV infection to demonstrate the pathogenesis of cellular injury. The combination of molecular expertise at UNSW with monoclonal antibody expertise from Abbott Diagnostics mean this project is unique worldwide.

胎儿和胎盘细胞巨细胞病毒（CMV）感染的分子和抗体分析。巨细胞病毒是一种乙型疱疹病毒，与细胞感染有许多未知的分子机制。病毒在体内感染胎盘细胞，尽管在体外研究病毒损伤这些细胞的发病机制非常困难。我们已经开始了一项研究，i)在体外证明胎盘细胞感染的分子伴随，ii)确定先天性巨细胞病毒感染的基因型特征，与雅培诊断公司合作，iii)建立巨细胞病毒感染的体内模型，以证明细胞损伤的发病机制。新南威尔士大学的分子专业知识与雅培诊断公司的单克隆抗体专业知识相结合，意味着该项目在全球范围内是独一无二的。