Centrifuge for high-capacity protein and DNA purification

所要求的设备将由一个跨学科的研究人员小组使用，以研究不同蛋白质在健康和疾病中的生理作用。所研究的蛋白质范围从心脏和中枢神经系统的离子通道、肾脏的转运体和大脑的神经递质受体，到用作林业中杀虫剂的生物替代品或抗癌药物的细菌毒素。研究人员提出的问题包括：离子通过细胞壁传输产生的渗透梯度如何影响局部过程，蛋白质内部重排的能量格局如何，以及细胞中的微小RNA片段如何影响我们的学习能力。此外，还研究了细菌产生的毒素，以找出它们如何作为抗癌药物应用。所有这些计划都有一个共同点，那就是它们都需要在细菌培养中生长DNA和蛋白质。所要求的离心机将用于收获这些培养物。

The equipment requested will be used by an interdisciplinary group of researchers to study the physiological role of different proteins in health and disease. The proteins studied range from ion channels in heart and central nervous system, transporters in the kidney and neurotransmitter receptors in the brain to bacterial toxins used as biological alternatives to pesticides in forestry or as anti-cancer drugs. The questions asked by the researchers include how the osmotic gradient generated by the transport of ions through the cell wall influences local processes, how the energy landscape of the internal rearrangement of a protein looks like and how small pieces of microRNA in the cell influence our capacity for learning. In addition, toxins produced by bacteria are studied to find out how they can be applied as an anti-cancer drug. All these programs have in common that they require growth of DNA and proteins in bacterial cultures. The requested centrifuge will be used to harvest these cultures.