Probing the energy landscape of conformational changes in membrane proteins

探索膜蛋白构象变化的能量景观

• 批准号: 327201-2012
• 负责人: Blunck, Rikard
• 金额: $ 3.28万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=549005
• 关键词: Probing; energy; landscape; conformational; changes

The function of membrane proteins is often related to a structural rearrangement. These may be described by kinetic models that provide macroscopic transition rates for the transition from one conformation to another. However, these rates are mainly determined by the probability that a certain event occurs, not by the movement itself. The information about interactions that form and break during the movement is hidden in ensemble measurements.

膜蛋白的功能通常与结构重排有关。这些可以通过动力学模型来描述，所述动力学模型提供从一种构象到另一种构象的转变的宏观转变速率。然而，这些比率主要由某一事件发生的概率决定，而不是由运动本身决定。在运动过程中形成和破坏的相互作用的信息隐藏在集合测量中。