Amino Acid and Peptide Radicals in Biochemistry and Synthesis

生物化学和合成中的氨基酸和肽自由基。本研究的目的是开发一个更好的基本了解的生化自由基反应的肽和蛋白质，特别是那些涉及超氧阴离子自由基和硫醇，和肽自由基的酶催化反应。通过这项工作获得的知识将用于生理活性氨基酸和肽的合成，以及建立调节生化自由基过程的方法。该研究的最终目标是开发方法和药物化合物，以预防和治疗与这些反应相关的人类疾病，并支持肽和蛋白质生物材料的商业开发。

Amino Acid and Peptide Radicals in Biochemistry and Synthesis. The aim of this research is to develop a better fundamental understanding of biochemical free radical reactions of peptides and proteins, particularly those involving superoxide radical anion and thiols, and peptide radicals in enzyme-catalysed reactions. Knowledge gained through this work will be used in the synthesis of physiologically active amino acids and peptides, as well as to establish ways to regulate biochemical free radical processes. The ultimate goal of the research is to develop methods and pharmaceutical compounds to prevent and treat human disorders associated with these reactions, and to underpin commercial exploitation of peptide and protein biomaterials.