Synthetic compounds to specifically activate or inhibit ryanodine receptor calcium ion channels

特异性激活或抑制兰尼定受体钙离子通道的合成化合物

• 批准号: LP0347486
• 负责人: Prof Christopher Easton
• 金额: $ 14.24万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0347486
• 关键词: Synthetic; compounds; specifically; activate; inhibit

The aim of the project is develop synthetic compounds that specifically and reversibly activate or inhibit ryanodine receptor calcium release channels, and will thus increase or reduce the force developed by skeletal muscle and the heart. The compounds will be useful in biomedical and veterinary sciences and in the livestock industry. Some of the compounds that are not effective on mammalian ryandine receptor isoforms might interact with insect channels and provide a template for a new class of insecticides. The compounds will be based on naturally occurring peptides which specifically and reversibly modulate mammalian calcium channels.

该项目的目的是开发一种合成化合物，可以特异性地、可逆地激活或抑制ryanodine受体钙释放通道，从而增加或减少骨骼肌和心脏产生的力。这些化合物将在生物医学和兽医科学以及畜牧业中发挥作用。一些对哺乳动物赖苯胺受体异构体无效的化合物可能与昆虫通道相互作用，并为一类新的杀虫剂提供模板。该化合物将基于天然存在的肽，其特异性和可逆地调节哺乳动物钙通道。