Exploitation of unusual patterns of reactivity of peptides towards radicals

利用肽对自由基的不寻常反应模式

• 批准号: DP150101425
• 负责人: Prof Christopher Easton
• 金额: $ 59.11万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150101425
• 关键词: Exploitation; unusual; patterns; reactivity; peptides

Life depends on free radical reactions of peptides and proteins but, for these compounds to exist, these must be inherently resistant to radicals. This project aims to combine state-of-the-art experiment and theoretical computations to build a detailed picture of peptide and protein radical reactivity, in order to explain this paradox and resolve ambiguities regarding processes through which radical damage to peptides occurs and is repaired. The project also aims to critically evaluate the basic concept of the fidelity of amino acid incorporation during protein biosynthesis. The results of this project could underpin the development of new strategies and therapeutics to treat human diseases, and new materials and synthetic methods to increase the utility of peptides in biotechnology.

生命依赖于肽和蛋白质的自由基反应，但是，对于这些化合物的存在，它们必须固有地抵抗自由基。该项目旨在将联合收割机最先进的实验和理论计算相结合，以建立肽和蛋白质自由基反应性的详细图像，以解释这一悖论并解决有关肽发生和修复自由基损伤的过程的模糊性。该项目还旨在批判性地评估蛋白质生物合成过程中氨基酸掺入保真度的基本概念。该项目的结果可以支持开发治疗人类疾病的新策略和疗法，以及增加肽在生物技术中的效用的新材料和合成方法。