Studies in neural plasticity

神经可塑性研究

• 批准号: 669-2009
• 负责人: Cain, Donald
• 金额: $ 1.6万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=473365
• 关键词: Studies; neural; plasticity

This research is aimed at understanding how the brain operates to allow rodents, and by extension humans, to learn and remember information. The research uses rodents learning to navigate in a simple laboratory task in a way that is similar to the way rodents learn to navigate in their environment to find and remember places containing food and water, mates, nesting sites, and other things important for survival. Some of the research involves making very small amounts of damage in very specific brain areas, or delivering very small amounts of electric current precisely to restricted brain sites, or the recording of brain electrical activity. The behavioral performance of the animals and the exact form and strength of the recorded brain activity will be used to infer how information is stored and retrieved. The expected benefits are a better understanding of how the brain stores and retrieves information, and better information for the development of treatments for brain disorders involving memory loss.

这项研究的目的是了解大脑如何运作，让啮齿动物，并通过扩展人类，学习和记忆信息。这项研究使用啮齿动物在一个简单的实验室任务中学习导航，其方式类似于啮齿动物在其环境中学习导航的方式，以寻找和记住包含食物和水，配偶，筑巢地点和其他对生存重要的东西的地方。一些研究涉及在非常特定的大脑区域制造非常少量的损伤，或者将非常少量的电流精确地输送到有限的大脑部位，或者记录大脑电活动。动物的行为表现以及记录的大脑活动的确切形式和强度将用于推断信息是如何存储和检索的。预期的好处是更好地了解大脑如何存储和检索信息，以及开发涉及记忆丧失的大脑疾病治疗方法的更好信息。