Connectome 2.0: Developing the next generation human MRI scanner for bridging studies of the micro-, meso- and macro-connectome

Connectome 2.0:开发下一代人体 MRI 扫描仪,用于桥接微观、中观和宏观连接组研究

基本信息

  • 批准号:
    10458018
  • 负责人:
  • 金额:
    $ 184.15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-09-21 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

SUMMARY We present Connectome 2.0, the next-generation human MRI scanner for imaging structural anatomy and connectivity spanning the microscopic, mesoscopic and macroscopic scales. This work builds upon our expertise in engineering the first human Connectome MRI scanner with 300 mT/m maximum gradient strength (Gmax), the highest ever achieved for a human system, for the Human Connectome Project (HCP). The goal of the HCP was to map the macroscopic structural connections of the in vivo healthy adult human brain using diffusion tractography. While this instrument has made important contributions to our understanding of macroscale connectional topology, our experience with the scanner over the last seven years has taught us that dedicated high-gradient performance scanners can also acquire a rich array of diffusion measurements that provide unparalleled in vivo assessment of neural tissue microstructure, such as the relative size and packing density of cells and axons. However, the current Connectome instrument is limited in its ability to resolve the full range of length scales needed to probe the microscopic and mesoscopic structure of the brain, due to basic design limitations, important technical elements, and biological interactions with the large rapidly switching gradients. Our experience with the first generation Connectome scanner and realization of its limitations motivates our multi-site proposal for the next generation human Connectome MRI scanner (Connectome 2.0) to achieve sensitivity to a broader range of cellular and axonal size scales, morphologies, and interconnections represented throughout the brain. Our goal here is to translate our initial experience into building a one-of-a-kind high-slew rate, ultra- high-gradient strength MRI scanner that is optimized for the study of neural tissue microstructure and neural circuits across multiple length scales. In order to maximize the resolution of this in vivo microscope for studies of the living human brain, we will push the diffusion resolution limit to unprecedented levels by (1) nearly doubling the current Gmax to 500 mT/m and tripling the maximum slew rate to 600 T/m/s; (2) pushing the limits of the RF receive coils and gradient characterization to enable maximum sensitivity with greatly reduced artifacts using real-time eddy current corrected dMRI acquisitions; (3) developing new pulse sequences to achieve the highest diffusion- and spatial-resolution ever achieved in vivo; and (4) calibrating the measurements obtained from this next generation instrument through systematic validation of the diffusion microstructural metrics in high-fidelity phantoms and ex vivo brain tissue at progressively finer scales. We envision creating the ultimate diffusion MRI machine capable of addressing the BRAIN 2025 mandate to image across scales, from the microscopic scale needed to probe cellular heterogeneity and plasticity, to the mesoscopic scale for enumerating the distinctions in cortical structure and connectivity that define cyto- and myeloarchitechtonic boundaries, to improvements in estimates of macroscopic connectivity.
总结

项目成果

期刊论文数量(0)
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科研奖励数量(0)
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PETER J. BASSER其他文献

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{{ truncateString('PETER J. BASSER', 18)}}的其他基金

Connectome 2.0: Developing the next generation human MRI scanner for bridging studies of the micro-, meso- and macro-connectome
Connectome 2.0:开发下一代人体 MRI 扫描仪,用于桥接微观、中观和宏观连接组研究
  • 批准号:
    10532483
  • 财政年份:
    2018
  • 资助金额:
    $ 184.15万
  • 项目类别:
Connectome 2.0: Developing the next generation human MRI scanner for bridging studies of the micro-, meso- and macro-connectome
Connectome 2.0:开发下一代人体 MRI 扫描仪,用于桥接微观、中观和宏观连接组研究
  • 批准号:
    10226118
  • 财政年份:
    2018
  • 资助金额:
    $ 184.15万
  • 项目类别:
Connectome 2.0: Developing the next generation human MRI scanner for bridging studies of the micro-, meso- and macro-connectome
Connectome 2.0:开发下一代人体 MRI 扫描仪,用于桥接微观、中观和宏观连接组研究
  • 批准号:
    9789878
  • 财政年份:
    2018
  • 资助金额:
    $ 184.15万
  • 项目类别:
Connectome 2.0: Developing the next generation human MRI scanner for bridging studies of the micro-, meso- and macro-connectome
Connectome 2.0:开发下一代人体 MRI 扫描仪,用于桥接微观、中观和宏观连接组研究
  • 批准号:
    10005356
  • 财政年份:
    2018
  • 资助金额:
    $ 184.15万
  • 项目类别:
Functional Properties of Extracellular Matrix
细胞外基质的功能特性
  • 批准号:
    6107994
  • 财政年份:
  • 资助金额:
    $ 184.15万
  • 项目类别:
Functional Properties of Extracellular Matrix
细胞外基质的功能特性
  • 批准号:
    6432511
  • 财政年份:
  • 资助金额:
    $ 184.15万
  • 项目类别:
Imaging Water Diffusion in the Brain and in Other Soft T
大脑和其他软 T 中水扩散的成像
  • 批准号:
    6991174
  • 财政年份:
  • 资助金额:
    $ 184.15万
  • 项目类别:
Physical-chemical Aspects Of Cell And Tissue Excitabilit
细胞和组织兴奋性的物理化学方面
  • 批准号:
    6677330
  • 财政年份:
  • 资助金额:
    $ 184.15万
  • 项目类别:
Imaging Water Diffusion in the Brain and in Other Soft Tissues
大脑和其他软组织中的水扩散成像
  • 批准号:
    8736807
  • 财政年份:
  • 资助金额:
    $ 184.15万
  • 项目类别:
Functional Properties Of Extracellular Matrix
细胞外基质的功能特性
  • 批准号:
    8736808
  • 财政年份:
  • 资助金额:
    $ 184.15万
  • 项目类别:

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