Synthesis of glycomimetics and gycodendrimers of biological interests

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Antibiotic resistance to bacterial infections is a major concern to health care systems. Hence new and alternative strategies to fight diseases are required and amongst these, prophylactic methods such as vaccinations have been extremely successful. Important infectious diseases like pneumonia, tuberculosis, and meningitis have been eradicated in developed countries due to massive vaccination programs. In this regard, our group has previously contributed to the commercialization of two such vaccines. We are proposing herein two novel and promising approaches aimed at preventing the early stage of infections by a) blocking bacteria from attaching and colonizing host tissues by virtue of their carbohydrate binding proteins present at the tip of their pilli and b) by stopping the assembly of these pilli using new therapies called pilicides. The likelihood of developing resistance is therefore greatly reduced since bacteria cannot mutate their carbohydrate receptors without impeding their attachment processes.