Interaction of bacterial antigens with insect cellular immunity

细菌抗原与昆虫细胞免疫的相互作用

• 批准号: 3406-2010
• 负责人: Dunphy, Gary
• 金额: $ 1.97万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=473702
• 关键词: Interaction; bacterial; antigens; insect; cellular

The insect pathogenic nematode, Steinernema carpocapsae, is commercially produced as an envrionmentally safe biological insecticide to control pest insects of importance to forestry, agriculture and horticulture. The infective nematode stage, which carries a lethal bacterium (Xenorhabdus nematophilus) in its gut, seeks out the insects and enters the insect's blood. The bacteria are released, destroy the antibacterial defences of the blood and kill the insect. Lipopolysaccharides(LPS),which are toxic molecules on the bacteria surface, enter the blood damaging the blood cells and inhibiting antibacterial enzymes.

昆虫病原线虫（steinerma carpocapsae）作为一种环境安全的生物杀虫剂被商业化生产，用于控制对林业、农业和园艺具有重要意义的害虫。感染性线虫阶段，在其肠道中携带一种致命的细菌（嗜线虫Xenorhabdus nematophilus），寻找昆虫并进入昆虫的血液。细菌被释放出来，破坏血液中的抗菌防御，杀死昆虫。脂多糖（LPS）是细菌表面的有毒分子，进入血液会破坏血细胞并抑制抗菌酶。