Musculoskeletal modeling and simulations of scoliotic standing postures

脊柱侧弯站立姿势的肌肉骨骼建模和模拟

• 批准号: 6160-2011
• 负责人: Allard, Paul
• 金额: $ 1.68万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=474067
• 关键词: Musculoskeletal; modeling; simulations; scoliotic; standing

Adolescent idiopathic scoliosis (AIS) is not only characterized by a deformed spine and rib cage distortion but also by altered head, shoulders and pelvis orientation in all three planes. Spinal deformity, morphology and posture are reflected in the body segment inertial parameters (BSIP). Though there is literature-based evidence that BSIP affects standing posture and balance little is known about their interaction with muscle control. The overall research goal is to develop musculoskeletal models focusing on the scoliotic trunk to simulate the effects BSIP in different upright stance conditions and estimate muscle activations required to restore balance in AIS girls. The specific objectives are to develop a generic able-bodied (AB) and three generic spine modules for small, moderate and severe deformity in the musculoskeletal models of SIMM/Opensim; simulate changes in BSIP and muscle moments on standing balance in 10 able-bodied and 30 AIS girls for eight upright stance conditions and simulate trunk muscles activation patterns using subject-specific models to improve standing balance in AIS. To perform these simulations personalized 3D spine data will be obtained by the EOS system, an ultra low dose digital X-ray radiation technique, available at the clinic and in-vivo personalized BSIP using methods developed in my previous Discovery grant. Standing balance will be quantified by two force plate and posture by a 6 camera video-based system. The spine modules to be developed in SIMM will then be imported into OpenSim for the simulations. These softwares are currently available in the laboratory. If modifying muscle moment can improve standing balance in AIS then these simulations will test which muscles are the most effective. Though we are using similar approaches in our shoulder model and others in modeling the lower limbs during locomotion no one addressed standing balance, asymmetrical standing postures and muscle simulations in scoliosis. This research develops the foundations for a scoliotic spine musculoskeletal model toolkit and provides a unique and novel advance with potential clinical impact leading to better posture training programs and improve body brace and spinal instrumentation.

青少年特发性脊柱侧凸（AIS）的特征不仅在于脊柱变形和胸廓变形，而且还在于头、肩和骨盆在所有三个平面上的方向改变。脊柱畸形、形态和姿势反映在身体节段惯性参数（BSIP）中。虽然有基于文献的证据表明BSIP影响站立姿势和平衡，但对它们与肌肉控制的相互作用知之甚少。总体研究目标是开发专注于脊柱侧凸躯干的肌肉骨骼模型，以模拟不同直立站立条件下BSIP的影响，并估计AIS女孩恢复平衡所需的肌肉激活。具体目标是在SIMM/Opensim的肌肉骨骼模型中开发一种通用健全（AB）和三种通用脊柱模块，用于小、中、重度畸形;模拟10名健全女孩和30名AIS女孩在8种直立站立条件下站立平衡时BSIP和肌肉力矩的变化，并使用受试者特定模型模拟躯干肌肉激活模式，以改善AIS的站立平衡。为了进行这些模拟，将通过EOS系统获得个性化3D脊柱数据，EOS系统是一种超低剂量数字X射线辐射技术，可在诊所和体内个性化BSIP中使用我以前的Discovery资助中开发的方法。站立平衡将通过两个测力板和基于6个摄像头的视频系统的姿势来量化。然后将在SIMM中开发的脊柱模块导入OpenSim进行模拟。这些软件目前都在实验室里。如果修改肌肉力矩可以改善AIS中的站立平衡，那么这些模拟将测试哪些肌肉最有效。虽然我们在肩部模型中使用了类似的方法，其他人在运动过程中对下肢建模时也使用了类似的方法，但没有人解决脊柱侧凸中的站立平衡、不对称站立姿势和肌肉模拟。这项研究为脊柱侧凸脊柱肌肉骨骼模型工具包奠定了基础，并提供了一个独特的和新颖的进步，具有潜在的临床影响，导致更好的姿势训练计划，并改善身体支具和脊柱器械。