Musculoskeletal modeling and simulations of scoliotic standing postures

脊柱侧弯站立姿势的肌肉骨骼建模和模拟

• 批准号: 6160-2011
• 负责人: Allard, Paul
• 金额: $ 1.68万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=568448
• 关键词: Musculoskeletal; modeling; simulations; scoliotic; standing

Adolescent idiopathic scoliosis (AIS) is not only characterized by a deformed spine and rib cage distortion but also by altered head, shoulders and pelvis orientation in all three planes. Spinal deformity, morphology and posture are reflected in the body segment inertial parameters (BSIP). Though there is literature-based evidence that BSIP affects standing posture and balance little is known about their interaction with muscle control. The overall research goal is to develop musculoskeletal models focusing on the scoliotic trunk to simulate the effects BSIP in different upright stance conditions and estimate muscle activations required to restore balance in AIS girls. The specific objectives are to develop a generic able-bodied (AB) and three generic spine modules for small, moderate and severe deformity in the musculoskeletal models of SIMM/Opensim; simulate changes in BSIP and muscle moments on standing balance in 10 able-bodied and 30 AIS girls for eight upright stance conditions and simulate trunk muscles activation patterns using subject-specific models to improve standing balance in AIS. To perform these simulations personalized 3D spine data will be obtained by the EOS system, an ultra low dose digital X-ray radiation technique, available at the clinic and in-vivo personalized BSIP using methods developed in my previous Discovery grant. Standing balance will be quantified by two force plate and posture by a 6 camera video-based system. The spine modules to be developed in SIMM will then be imported into OpenSim for the simulations. These softwares are currently available in the laboratory. If modifying muscle moment can improve standing balance in AIS then these simulations will test which muscles are the most effective. Though we are using similar approaches in our shoulder model and others in modeling the lower limbs during locomotion no one addressed standing balance, asymmetrical standing postures and muscle simulations in scoliosis. This research develops the foundations for a scoliotic spine musculoskeletal model toolkit and provides a unique and novel advance with potential clinical impact leading to better posture training programs and improve body brace and spinal instrumentation.

青少年特发性脊柱侧凸(AIS)不仅以脊柱和肋骨变形为特征，而且在所有三个平面上都有头、肩和骨盆方向的改变。脊柱的畸形、形态和姿势反映在身体节段惯性参数(BSIP)中。虽然有基于文献的证据表明，BSIP影响站立姿势和平衡，但对它们与肌肉控制的相互作用知之甚少。总体研究目标是开发以脊柱侧弯躯干为重点的肌肉骨骼模型，以模拟不同直立姿势条件下的BSIP效应，并估计AIS女孩恢复平衡所需的肌肉激活。具体目标是开发一个通用的健全(AB)和三个通用脊柱模块，用于SIMM/OpenSim肌肉骨骼模型中的小、中、重度畸形；模拟10名健全女孩和30名AIS女孩在8种直立站姿条件下站立平衡时的BSIP和肌肉力矩的变化，并使用特定于对象的模型模拟躯干肌肉激活模式，以改善AIS的站立平衡。为了进行这些模拟，个性化的3D脊柱数据将由EOS系统获得，EOS系统是一种超低剂量的数字X射线辐射技术，可在临床和体内使用我之前的发现资助中开发的方法进行个性化的BSIP。站立平衡将由两个力板量化，姿势将通过6个摄像头的视频系统进行量化。然后将在SIMM中开发的脊椎模块导入到OpenSim中进行模拟。这些软件目前已在实验室中使用。如果修改肌肉力矩可以改善AIS中的站立平衡，那么这些模拟将测试哪些肌肉最有效。虽然我们在我们的肩部模型中使用了类似的方法，在运动过程中也使用了其他方法来模拟腿部，但没有人研究脊柱侧弯时的站立平衡、不对称站立姿势和肌肉模拟。这项研究为脊柱侧弯脊柱肌肉骨骼模型工具包的开发奠定了基础，并提供了具有潜在临床影响的独特和新颖的进展，导致更好的姿势训练计划，并改进身体支撑和脊柱内固定。