Mutational analyses of learning and memory

学习和记忆的突变分析

• 批准号: 8319-2008
• 负责人: vanderKooy, Derek
• 金额: $ 3.06万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=474373
• 关键词: Mutational; analyses; learning; memory

Our goal is to use the power and specificity of modern molecular genetics to reveal the component processes of learning and memory. In undertaking a mutational screening approach to learning and memory, we have taken advantage of the best known multicellular organism, the nematode C.elegans. C.elegans has proven to be an excellent molecular model for mammalinan (including human) biochemical functions. We will use the C.elegans learning and memory genes discovered to find their relevant mammalian homologues. Most important, the C.elegans mutants should allow us to ask if we can separate associative from nonassociative learning, immediate from longer term memory, storage from retrieval, and learning and memory in one sensory modality from those in another sensory modality.

我们的目标是利用现代分子遗传学的力量和特异性来揭示学习和记忆的组成过程。 在对学习和记忆进行突变筛选方法时，我们利用了最著名的多细胞生物——线虫线虫。 线虫已被证明是哺乳动物（包括人类）生化功能的优秀分子模型。 我们将利用发现的线虫学习和记忆基因来寻找其相关的哺乳动物同源物。 最重要的是，线虫突变体应该让我们思考是否可以将联想学习与非联想学习、即时记忆与长期记忆、存储与检索、以及一种感觉模式与另一种感觉模式的学习和记忆分开。