Mutational Analyses of Learning and Memory

学习和记忆的突变分析

• 批准号: 8319-2013
• 负责人: vanderKooy, Derek
• 金额: $ 4.15万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=592917
• 关键词: Mutational; Analyses; Learning; Memory

Our goal is to use the power and specificity of modern mutational molecular genetics to reveal the component processes of learning and memory. There are two routes to mutant analysis: candidate gene targeting (reverse genetics) and screening (forward genetics) approaches. The candidate targeting approach involves identifying specific genes that are candidates for important roles in learning or memory, and then testing the effects of targeted mutations of these genes (naturally occurring or experimenter induced) in various learning paradigms.

我们的目标是利用现代突变分子遗传学的力量和特异性来揭示学习和记忆的组成过程。突变体分析有两种途径：候选基因靶向（反向遗传学）和筛选（正向遗传学）方法。候选靶向方法涉及鉴定在学习或记忆中起重要作用的特定基因，然后测试这些基因的靶向突变（自然发生的或实验者诱导的）在各种学习范式中的作用。