Mutational analyses of learning and memory

学习和记忆的突变分析

• 批准号: 8319-2008
• 负责人: vanderKooy, Derek
• 金额: $ 3.06万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=513319
• 关键词: Mutational; analyses; learning; memory

Our goal is to use the power and specificity of modern molecular genetics to reveal the component processes of learning and memory. In undertaking a mutational screening approach to learning and memory, we have taken advantage of the best known multicellular organism, the nematode C.elegans. C.elegans has proven to be an excellent molecular model for mammalinan (including human) biochemical functions. We will use the C.elegans learning and memory genes discovered to find their relevant mammalian homologues. Most important, the C.elegans mutants should allow us to ask if we can separate associative from nonassociative learning, immediate from longer term memory, storage from retrieval, and learning and memory in one sensory modality from those in another sensory modality.

我们的目标是利用现代分子遗传学的力量和特异性来揭示学习和记忆的组成过程。 在进行突变筛选的方法来学习和记忆，我们已经利用了最有名的多细胞生物，线虫秀丽隐杆线虫。 秀丽隐杆线虫已被证明是研究哺乳动物（包括人类）生化功能的极好分子模型。 我们将利用已发现的秀丽隐杆线虫学习记忆基因来寻找它们的相关哺乳动物同源基因。 最重要的是，秀丽隐杆线虫的突变体应该让我们能够问，我们是否可以区分联想学习和非联想学习、即时记忆和长期记忆、存储和提取，以及一种感觉方式的学习和记忆与另一种感觉方式的学习和记忆。