Biochemical properties of S-nitroso-myoglobin and its role in regulating nitric oxide bio-availability

S-亚硝基肌红蛋白的生化特性及其在调节一氧化氮生物利用度中的作用。一氧化氮（NO）刺激血管扩张。血管扩张对维持血压至关重要。NO调节的改变导致血管功能障碍。在血管内，肌红蛋白通过氧化和结合反应调节NO浓度。相比之下，S-亚硝基肌红蛋白代表了人类NO的新来源。本研究的目的是通过确定S-亚硝基肌红蛋白的化学稳定性，形成和衰减速率，人体血管中的浓度以及它是否能引起与真实NO类似的血管扩张来扩展肌红蛋白对NO调节的知识。这种新的数据代表了理解肌红蛋白在NO稳态中的作用的重大基本进展。

Biochemical properties of S-nitroso-myoglobin and its role in regulating nitric oxide bio-availability. Nitric oxide (NO) stimulates blood vessel dilation. Vessel dilation is essential to maintaining blood pressure. Altered NO-regulation leads to vessel dysfunction. Within blood vessels, myoglobin regulates NO concentrations through oxidation and binding reactions. In contrast, S-nitroso-myoglobin represents a novel source of NO in humans. The goal of this study is to expand the knowledge on NO-regulation by myoglobin through determining S-nitroso-myoglobin's - chemical stability, rates of formation and decay, concentration in human vessels and whether it can cause blood vessel dilation similar to authentic NO. Such novel data represents a major fundamental advance in understanding the role of myoglobin in NO-homeostasis.