Role of nemo in patterning the drosophila eye and head

尼莫在果蝇眼睛和头部图案化中的作用

• 批准号: 203545-2008
• 负责人: Verheyen, Esther
• 金额: $ 2.55万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=477162
• 关键词: Role; nemo; patterning; drosophila; eye

The genes that control eye specification in different animals and insects are highly conserved, yet they specify the formation of vastly different eye structure across these species. In this proposal, we describe experiments to study the role of the Nemo protein in specifying eye and head fates in the fruit fly Drosophila. In the development of the head and eye structures, there are certain genes that act to repress head fate, thus promoting eyes. Other genes repress retinal eye fate and promote head cell identity. Some play roles in both processes. The proteins that carry out these diverse functions are regulated through multiple tiers of protein-protein interactions. Our studies of Nemo have revealed that Nemo is required to suppress the function of certain head-promoting proteins, while being required for the activity of certain retinal proteins. Thus Nemo seems to play an integral role in ensuring the proper balance between the opposing activities that occur during the development of the organism.

在不同的动物和昆虫中控制眼睛特化的基因是高度保守的，但它们指定了这些物种之间差异巨大的眼睛结构的形成。 在这个建议中，我们描述的实验，研究的Nemo蛋白在指定的眼睛和头部的命运在果蝇的作用。 在头部和眼睛结构的发育过程中，某些基因会抑制头部的命运，从而促进眼睛的发育。 其他基因抑制视网膜眼的命运，促进头细胞的身份。 有些人在这两个过程中发挥作用。 执行这些不同功能的蛋白质通过多层蛋白质-蛋白质相互作用进行调节。 我们对Nemo的研究表明，Nemo需要抑制某些头部促进蛋白的功能，同时需要某些视网膜蛋白的活性。 因此，尼莫似乎在确保有机体发育过程中发生的对立活动之间的适当平衡方面发挥着不可或缺的作用。