Bioprocess development for the large scale production and differentiation of mammalian adult stem cells

哺乳动物成体干细胞大规模生产和分化的生物工艺开发

• 批准号: 288129-2008
• 负责人: Sen, Arindom
• 金额: $ 1.61万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=480378
• 关键词: Bioprocess; development; large; scale; production

The human body is composed of about 200 different types of specialized cells. These specialized cell types combine in different proportions to form the various tissues found in organs such as the brain, heart, skin, liver and pancreas. Adult mammalian tissues are also known to contain a sparse population of stem cells. The role of these adult stem cells is to maintain the tissue in which they reside by replacing cells which die due to normal wear and tear, or injury. This awesome ability to regenerate any of the numerous specialized cell types found in a given tissue has lead to a rapid increase in the amount of research aimed at developing stem cell applications. Adult stem cells could be used to better understand normal development, test new pharmaceuticals, learn about aging, and develop new therapies which could improve the health and wellbeing of Canadians. However, the development of stem cell applications requires researchers to have access to an adequate supply of stem cells. Unfortunately, due to their sparse nature in adult tissues, stem cells can only be procured in very small quantities, thereby significantly hampering research efforts.

人体由大约200种不同类型的特化细胞组成。这些特化的细胞类型以不同的比例联合收割机形成在诸如脑、心脏、皮肤、肝脏和胰腺等器官中发现的各种组织。还已知成年哺乳动物组织含有稀疏的干细胞群体。这些成体干细胞的作用是通过替换由于正常磨损或损伤而死亡的细胞来维持它们所居住的组织。这种在给定组织中发现的众多专门细胞类型中的任何一种再生的令人敬畏的能力导致了旨在开发干细胞应用的研究数量的迅速增加。成人干细胞可用于更好地了解正常发育，测试新药，了解衰老，并开发新的治疗方法，以改善加拿大人的健康和福祉。然而，干细胞应用的发展需要研究人员获得足够的干细胞供应。不幸的是，由于它们在成人组织中的稀疏性，干细胞只能以非常小的数量获得，从而大大阻碍了研究工作。