Gene expression in programmed cell death

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Programmed cell death (apoptosis) is essential for the normal development and tissue function of all animals. Changes in the expression of cell death genes can promote apoptosis. My laboratory has discovered a pivotal new cellular signaling pathway that controls life versus death decisions termed the TAF6delta pathway. Here we propose a research program designed to define the molecular mechanisms by which TAF6delta induces cell death. We have two major goals, 1) the identification of the genes controlled by TAF6delta that cause cell death, and 2) the identification of the proteins that act upstream of TAF6delta to control its expression.