Molecular negotiations at the host-parasite interface

宿主-寄生虫界面的分子谈判

• 批准号: 326946-2011
• 负责人: Geary, Timothy
• 金额: $ 4.08万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=481507
• 关键词: Molecular; negotiations; host; parasite; interface

Parasitism is the commonest life-style for animals, yet hosts resist almost all parasite species; each host has a set of relatively specific parasites. Host defense systems provide inhospitable conditions for the vast majority of parasite species. The molecular negotiations between parasite and host that enable parasite success underlie a fundamental aspect of life: how to prevent parasitism to conserve nutritional resources (on the part of the host) and how to evade host defenses to reproduce (on the part of the parasite). The molecules deployed in this negotiation are poorly understood; our research aims to develop a better understanding of how parasites overcome host defenses and usurp host resources. We used genomic/proteomic approaches to identify proteins secreted by a filarial parasitic nematode, Brugia malayi, and showed that the main drug for filariasis, ivermectin, blocks protein secretion by the parasite.

寄生是动物最常见的生活方式，但宿主对几乎所有寄生虫种类都有抵抗力；每个宿主都有一组相对特定的寄生虫。宿主防御系统为绝大多数寄生虫物种提供了不适宜生存的条件。寄生虫和宿主之间的分子谈判使寄生虫能够成功，这是生命的一个基本方面的基础：如何防止寄生以保存营养资源（就宿主而言）以及如何逃避宿主防御以进行繁殖（就寄生虫而言）。人们对这次谈判中使用的分子知之甚少。我们的研究旨在更好地了解寄生虫如何克服宿主防御并侵占宿主资源。我们使用基因组/蛋白质组学方法来鉴定丝虫寄生线虫马来丝虫分泌的蛋白质，并表明治疗丝虫病的主要药物伊维菌素可阻止寄生虫的蛋白质分泌。