Molecular negotiations at the host-parasite interface

宿主-寄生虫界面的分子谈判

• 批准号: 326946-2011
• 负责人: Geary, Timothy
• 金额: $ 4.08万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=526750
• 关键词: Molecular; negotiations; host; parasite; interface

Parasitism is the commonest life-style for animals, yet hosts resist almost all parasite species; each host has a set of relatively specific parasites. Host defense systems provide inhospitable conditions for the vast majority of parasite species. The molecular negotiations between parasite and host that enable parasite success underlie a fundamental aspect of life: how to prevent parasitism to conserve nutritional resources (on the part of the host) and how to evade host defenses to reproduce (on the part of the parasite). The molecules deployed in this negotiation are poorly understood; our research aims to develop a better understanding of how parasites overcome host defenses and usurp host resources. We used genomic/proteomic approaches to identify proteins secreted by a filarial parasitic nematode, Brugia malayi, and showed that the main drug for filariasis, ivermectin, blocks protein secretion by the parasite.

寄生是动物最常见的生活方式，但宿主几乎抵抗所有的寄生虫物种;每个宿主都有一套相对特定的寄生虫。宿主防御系统为绝大多数寄生虫提供了不适宜生存的条件。寄生虫和宿主之间的分子谈判，使寄生虫成功的基础上的一个基本方面的生活：如何防止寄生保存营养资源（对主机的一部分）和如何逃避主机的防御繁殖（对寄生虫的一部分）。在这种谈判中部署的分子知之甚少;我们的研究旨在更好地了解寄生虫如何克服宿主防御和篡夺宿主资源。我们使用基因组/蛋白质组学的方法来确定由丝虫寄生线虫，马来丝虫分泌的蛋白质，并表明，丝虫病的主要药物，伊维菌素，阻断寄生虫的蛋白质分泌。