Molecular negotiations at the host-parasite interface

宿主-寄生虫界面的分子谈判

• 批准号: RGPIN-2016-06602
• 负责人: Geary, Timothy
• 金额: $ 3.93万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629803
• 关键词: Molecular; negotiations; host; parasite; interface

The success or failure of an infection depends on the outcome of a molecular dialog between host and pathogen. This is especially true for large metazoan parasites such as nematodes, which infect the gastrointestinal tract and internal tissues. Hosts resist infection by almost all parasite species, and host-parasite interactions are typically quite specific. How this fundamental aspect of nematode parasitism is determined at the molecular level remains a mystery. Our driving hypothesis is that molecules secreted by parasitic nematodes selectively and specifically modulate host immune responses that would normally prevent infection. Parasite molecules interact with host immune cells at the receptor level and at the level of gene regulation. These interactions are specific for permissive hosts and establish the molecular basis of host-parasite specificity. Understanding the molecules used by parasites to accomplish this immunomodulation will reveal the molecular basis for host-parasite specificity and illuminate the evolutionary processes involved in parasitism.

感染的成功或失败取决于宿主和病原体之间分子对话的结果。这对于大型后生动物寄生虫如线虫尤其如此，其感染胃肠道和内部组织。寄生虫抵抗几乎所有寄生虫的感染，宿主-寄生虫相互作用通常是非常特异的。线虫寄生的这个基本方面是如何在分子水平上决定的仍然是一个谜。我们的驱动假说是，寄生线虫分泌的分子选择性和特异性调节宿主的免疫反应，通常会防止感染。寄生虫分子在受体水平和基因调控水平与宿主免疫细胞相互作用。这些相互作用对允许宿主是特异性的，并建立了宿主-寄生虫特异性的分子基础。了解寄生虫用于完成这种免疫调节的分子将揭示宿主-寄生虫特异性的分子基础，并阐明寄生虫所涉及的进化过程。