Computational diffusion magnetic resonance imaging: acquisition, modeling, processing and visualization to study brain connectivity and tissue microstructure

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Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, and other neurodegenerative diseases currently impact on a large proportion of the aging Canadian population. It remains unknown how fiber connections in the brain white matter are degenerated and damaged by these diseases. Diffusion magnetic resonance imaging (MRI) is the only non-invasive technique able to obtain information about the neural architecture of the white matter. Diffusion MRI has proven of utmost importance in the past 10 years in a wide range of neuroscience studies; for neurodegerative diseases as aformentioned, but also for brain development studies and neuro-surgical planning. Hence, diffusion MRI provides a unique tool to study anatomical connectivity and better understand how the brain is wired.