Improving cholesterol efflux by targeted disruption of hepatic lipase interactions with the cell surface

通过有针对性地破坏肝脂肪酶与细胞表面的相互作用来改善胆固醇流出

• 批准号: 254763
• 负责人: Brown Robert J
• 金额: $ 4.96万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-09-01 至 2014-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=254763&lang=en
• 关键词: Cholesterol; Cholesterol Efflux; Hepatic Lipase; High Density Lipoprotein; Nuclear Magnetic Resonance (Nmr); Peptide Drugs; Protein Purification; Protein Structure; Recombinant Protein; Reverse Cholesterol Transport

Heart disease is the leading cause of death in the Western world. The blockage of blood vessels is one of the major causes of this disease. The blockage is initiated by the uptake of blood fats carried by "bad cholesterol" (or LDL) into blood vessel walls

心脏病是西方世界的主要死因。血管阻塞是这种疾病的主要原因之一。这种阻塞是由“坏胆固醇”(或低密度脂蛋白)携带的血液脂肪进入血管壁引起的。