Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
基本信息
- 批准号:401938-2011
- 负责人:
- 金额:$ 2.55万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2011
- 资助国家:加拿大
- 起止时间:2011-01-01 至 2012-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Spirochetes are highly motile helical or planar wave-form bacteria whose motility is thought to depend on adhesion to components of the extracellular environment. However, if motility is dependent on adhesion, then adhesion complexes must be dynamic for spirochete movement to occur. Spirochetes must also coordinate motility and adhesion in the presence of fluid shear forces, which can disrupt bacterial adhesion and migration on surfaces in the natural environment, and could alter both the motile and adhesive properties of these bacteria. The properties and mechanisms underlying dynamic coordination of spirochete adhesion and motility in the presence of fluid shear forces are not yet defined. Early efforts to investigate the relationship between spirochete motility and adhesion were impeded by the inability to disrupt these functions genetically and the absence of appropriate dynamic live cell observation and labelling methods. Recent advances finally permit investigation of the dynamic coordination of motility and adhesion in a living spirochete, the Lyme disease pathogen Borrelia burgdorferi (Bb). The overall objective of my research program is to investigate the fundamental properties and mechanisms underlying coordination of adhesion and motility in Bb subjected to fluid shear forces. My short-term objective is to use live cell imaging approaches to define the dynamic relationship between spirochete motility and adhesion, and the effect of fluid shear forces on these functions. My long-term objective is to develop appropriate methodologies for investigating the biophysical properties and mechanisms coordinating Bb adhesion and motility under fluid shear forces. These studies will provide the first dynamic insight into mechanisms coordinating motility and adhesion in spirochetes, and the effect of fluid shear forces on these processes.
螺旋体是高度能动的螺旋或平面波形细菌,其能动性被认为取决于对细胞外环境组分的粘附。然而,如果运动依赖于粘附,那么粘附复合物必须是动态的螺旋体运动发生。螺旋体还必须在流体剪切力的存在下协调运动性和粘附性,这可以破坏自然环境中表面上的细菌粘附和迁移,并且可以改变这些细菌的运动性和粘附性。螺旋体粘附和运动在流体剪切力的存在下的动态协调的属性和机制尚未确定。早期的努力,调查螺旋体运动和粘附之间的关系受到阻碍,无法破坏这些功能的遗传和缺乏适当的动态活细胞观察和标记方法。最近的进展终于允许调查的动态协调运动和粘附在一个活的螺旋体,莱姆病病原体伯氏疏螺旋体(Bb)。我的研究计划的总体目标是调查的基本属性和机制的协调Bb受到流体剪切力的粘附和运动。我的短期目标是使用活细胞成像方法来确定螺旋体运动和粘附之间的动态关系,以及流体剪切力对这些功能的影响。我的长期目标是制定适当的方法,调查的生物物理特性和机制协调BB的粘附和运动下流体剪切力。这些研究将提供第一个动态的洞察机制,协调运动和粘附螺旋体,以及流体剪切力对这些过程的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Moriarty, Tara其他文献
Moriarty, Tara的其他文献
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{{ truncateString('Moriarty, Tara', 18)}}的其他基金
Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
- 批准号:
RGPIN-2017-06403 - 财政年份:2021
- 资助金额:
$ 2.55万 - 项目类别:
Discovery Grants Program - Individual
Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
- 批准号:
RGPIN-2017-06403 - 财政年份:2020
- 资助金额:
$ 2.55万 - 项目类别:
Discovery Grants Program - Individual
Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
- 批准号:
RGPIN-2017-06403 - 财政年份:2019
- 资助金额:
$ 2.55万 - 项目类别:
Discovery Grants Program - Individual
Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
- 批准号:
RGPIN-2017-06403 - 财政年份:2018
- 资助金额:
$ 2.55万 - 项目类别:
Discovery Grants Program - Individual
Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
- 批准号:
RGPIN-2017-06403 - 财政年份:2017
- 资助金额:
$ 2.55万 - 项目类别:
Discovery Grants Program - Individual
Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
- 批准号:
401938-2011 - 财政年份:2015
- 资助金额:
$ 2.55万 - 项目类别:
Discovery Grants Program - Individual
Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
- 批准号:
401938-2011 - 财政年份:2014
- 资助金额:
$ 2.55万 - 项目类别:
Discovery Grants Program - Individual
Screening technologies for identification of bacterial vascular dissemination inhibitors and testing of novel antibioticcomplementing therapeutic molecules
细菌血管传播抑制剂的筛选技术和新型抗生素补充治疗分子的测试
- 批准号:
446650-2013 - 财政年份:2014
- 资助金额:
$ 2.55万 - 项目类别:
Collaborative Health Research Projects
Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
- 批准号:
401938-2011 - 财政年份:2013
- 资助金额:
$ 2.55万 - 项目类别:
Discovery Grants Program - Individual
Screening technologies for identification of bacterial vascular dissemination inhibitors and testing of novel antibioticcomplementing therapeutic molecules
细菌血管传播抑制剂的筛选技术和新型抗生素补充治疗分子的测试
- 批准号:
446650-2013 - 财政年份:2013
- 资助金额:
$ 2.55万 - 项目类别:
Collaborative Health Research Projects
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Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
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Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
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- 资助金额:
$ 2.55万 - 项目类别:
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Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
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- 资助金额:
$ 2.55万 - 项目类别:
Discovery Grants Program - Individual
Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
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Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
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Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
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$ 2.55万 - 项目类别:
Discovery Grants Program - Individual
Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
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Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
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Spirochete coordination of adhesion and motility in the presence of fluid shear forces
存在流体剪切力时螺旋体粘附和运动的协调
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