Assessing the role of corticostriatal interactions in appetitive and aversive conditioning- relevance to addiction and schizophrenia

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The mammalian brain is capable of processing and retaining a large amount of new information, by forming meaningful relationships between neutral stimuli in the environment with motivationally significant events. Once formed, these associations (as memories) can exert a powerful influence over our thoughts, emotions, actions, and decisions, sometimes to the extent that they can give rise to abnormal manifestations of behaviour, as seen in addiction, schizophrenia, or phobia. Thus, it is crucial that research is directed towards furthering our understanding of how the brain is organized to optimize the regulation of associative information acquisition, and its subsequent control over behavioural output.