The Computational Role of Corticostriatal Circuits in Binge-Eating Disorder Symptoms and Severity
皮质纹状体回路在暴食症症状和严重程度中的计算作用
基本信息
- 批准号:10593579
- 负责人:
- 金额:$ 25.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-12-01 至 2024-11-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAgeAmericanAnorexia NervosaBehaviorBehavior ControlBehavior DisordersBehavioralBinge EatingBinge eating disorderBody mass indexBrainBulimiaCOVID-19CharacteristicsChronic DiseaseClinicalCognitiveCognitive deficitsComputer ModelsCorpus striatum structureDataDecision MakingDiagnosisDiagnosticDiseaseDistressDopamineDorsalEating BehaviorEating DisordersEnvironmentExanthemaExposure toFeedbackFoodFrequenciesFunctional Magnetic Resonance ImagingFutureGoalsHealthHeterogeneityHumanHyperphagiaImpairmentImpulsivityIndividualInterruptionInterventionKnowledgeLearningLinkMatched GroupMeasuresMedicalModelingMorbidity - disease rateNeurobiologyNeurotransmittersOutcomePatient Self-ReportPatientsPatternPersonsPhasePilot ProjectsProcessRecurrenceReportingResearchResponse to stimulus physiologyRoleSensorySeveritiesStimulusSymptomsSystemTestingTheoretical modelWorkanorexia nervosa binge-purge subtypebrain basedcausal modeldisabilityeating pathologyefficacious interventionexperiencegoal oriented behaviorhigh rewardindexingneuralneural circuitneural modelneuromechanismnovelpre-clinical researchpredictive modelingpsychologicreinforced behaviorresponsesexsimulationsuicidaltheoriestreatment response
项目摘要
PROJECT SUMMARY/ABSTRACT
Binge-eating disorder (BED) is more common than any other eating disorder in the US and is associated with
high rates of medical morbidity, disability, and suicidality. As roughly half of patients with BED remain
symptomatic after current first-line treatments, there is a critical need to identify brain-based factors that
perpetuate BED symptoms and that may serve as mechanistic targets for novel treatments. Current theoretical
models posit that the recurrent, distressing, and out-of-control overeating that characterizes BED arises after a
transition from ventral to dorsal corticostriatal circuit control over decision-making, and a corresponding shift
from goal-oriented to habitual behavior. However, individuals with BED present with a co-occurrence of
seemingly contradictory decision-making problems—impulsivity and perseveration—and a wide range of
binge-eating severity. Neurobiological research to date has failed to account for this within-person combination
of cognitive deficits or this between-person variability in symptoms. The goal of this R21 project is to test a
neurocomputational model of BED that provides a more comprehensive account of symptoms and severity.
This model expands on previous theories and links behavior to effective connectivity in corticostriatal circuits
underlying decision-making. Specifically, the proposed study combines computational modeling of behavior
with dynamic causal modeling (DCM) of neural connectivity to examine whether aberrant within- and between-
circuit dynamics relate to cognitive and clinical symptom profiles in BED. We will compare effective connectivity
of 28 adults with BED to that of 28 group-matched healthy controls during two decision-making paradigms. We
will test two overarching predictions that are informed by our simulations of corticostriatal circuit dynamics and
associated behavior: 1) In individuals with BED, aberrant within-circuit dynamics, specifically overstability (high
“gain”) within dorsal and ventral corticostriatal circuits, result in overweighting of initial evidence (leading to
impulsivity) and promote choice selections that are insensitive to changes in the environment (perseveration);
2) In individuals with BED, aberrant between-circuit dynamics, specifically an over-influence of one
corticostriatal circuit on the other (dorsal on ventral or vice-versa), promote more severe binge eating. These
model predictions can explain the impulsive, out-of-control initiation of binge eating, why individuals with BED
continue to binge eat despite fullness and distress (i.e., perseverate), and why some individuals with BED are
more likely than others to more frequently initiate binge eating episodes. As such, data from this proof-of-
concept pilot study will substantiate a novel neurocomputational model of BED symptoms and characterize
alterations in neural circuit dynamics, not just neural activation, in BED. In addition, the data will support a
future R01 application focused on testing the model among a wider diagnostic spectrum of individuals who
binge eat. This work can ultimately inform new interventions with circuit-based targets to more effectively
interrupt entrenched patterns of binge eating.
项目摘要/摘要
暴饮暴食障碍(Bed)在美国比任何其他饮食障碍都更常见,并与
医疗发病率、伤残率和自杀率很高。因为大约一半的卧床不起的患者
在目前的一线治疗后出现症状,迫切需要确定基于大脑的因素
使卧床症状永久化,这可能成为新治疗的机械靶点。当前的理论
模型假设,床上反复出现的、令人痛苦的和失控的暴饮暴食是在
从腹侧皮质纹状体回路到背侧皮质纹状体回路控制决策的转变,以及相应的转变
从目标导向到习惯性行为。然而,有床的人同时出现
看似矛盾的决策问题--冲动和坚持不懈--以及广泛的
暴食的严重性。到目前为止,神经生物学研究还未能解释这种人内结合。
认知缺陷或这种人与人之间的症状差异。这个R21项目的目标是测试一个
BED的神经计算模型,可更全面地说明症状和严重程度。
该模型扩展了以前的理论,并将行为与皮质纹状体回路的有效连通性联系起来
潜在的决策制定。具体地说,建议的研究结合了行为的计算模型
使用神经连接的动态因果建模(DCM)来检查内部和之间的异常
回路动力学与认知和临床症状在床上的特征有关。我们将比较有效的连接
在两种决策范式中,28名成人卧床与28名健康对照组进行配对。我们
将测试两个主要的预测,这两个预测是由我们对皮质纹状体回路动力学和
相关行为:1)在有床的个体中,异常的回路内动力学,特别是过度稳定(高
“增益”)在背侧和腹侧皮质纹状体环路内,导致初步证据的过重(导致
冲动),促进对环境变化不敏感的选择(坚持不懈);
2)在有床的人中,异常的回路间动力学,特别是一个人的过度影响
皮质纹状体回路在另一端(背侧在腹侧或反之亦然),促进更严重的暴饮暴食。这些
模型预测可以解释暴饮暴食的冲动和失控,以及为什么人们会上床
在饱腹和痛苦的情况下继续暴饮暴食(即,坚持),以及为什么一些有床的人
比其他人更容易引发暴饮暴食。因此,来自这一证据的数据-
概念性初步研究将证实一种新的卧床症状的神经计算模型并表征
在床上,神经回路动力学的改变,而不仅仅是神经激活。此外,数据还将支持
未来的R01应用程序侧重于在更广泛的诊断范围内测试该模型
暴饮暴食。这项工作最终可以为基于电路的目标的新干预提供信息,以更有效地
打破根深蒂固的暴饮暴食模式。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Laura A. Berner其他文献
43.5 CORTICAL THICKNESS AND ATTENTIONAL DEFICITS ACROSS THE LIFESPAN IN BULIMIA NERVOSA
- DOI:
10.1016/j.jaac.2016.07.376 - 发表时间:
2016-10-01 - 期刊:
- 影响因子:
- 作者:
Laura A. Berner - 通讯作者:
Laura A. Berner
Restoring Weight and Brain Function: Intrinsic Neural Activity and Connectivity Alterations as State Markers of Adolescent Anorexia Nervosa.
恢复体重和大脑功能:内在神经活动和连接性改变作为青少年神经性厌食症的状态标志。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Laura A. Berner;B. Shevlin - 通讯作者:
B. Shevlin
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
ENIGMA 与全球神经科学:十年多来自 40 多个国家对健康和疾病大脑的大规模研究
- DOI:
10.1038/s41398-020-0705-1 - 发表时间:
2020-03-20 - 期刊:
- 影响因子:6.200
- 作者:
Paul M. Thompson;Neda Jahanshad;Christopher R. K. Ching;Lauren E. Salminen;Sophia I. Thomopoulos;Joanna Bright;Bernhard T. Baune;Sara Bertolín;Janita Bralten;Willem B. Bruin;Robin Bülow;Jian Chen;Yann Chye;Udo Dannlowski;Carolien G. F. de Kovel;Gary Donohoe;Lisa T. Eyler;Stephen V. Faraone;Pauline Favre;Courtney A. Filippi;Thomas Frodl;Daniel Garijo;Yolanda Gil;Hans J. Grabe;Katrina L. Grasby;Tomas Hajek;Laura K. M. Han;Sean N. Hatton;Kevin Hilbert;Tiffany C. Ho;Laurena Holleran;Georg Homuth;Norbert Hosten;Josselin Houenou;Iliyan Ivanov;Tianye Jia;Sinead Kelly;Marieke Klein;Jun Soo Kwon;Max A. Laansma;Jeanne Leerssen;Ulrike Lueken;Abraham Nunes;Joseph O’ Neill;Nils Opel;Fabrizio Piras;Federica Piras;Merel C. Postema;Elena Pozzi;Natalia Shatokhina;Carles Soriano-Mas;Gianfranco Spalletta;Daqiang Sun;Alexander Teumer;Amanda K. Tilot;Leonardo Tozzi;Celia van der Merwe;Eus J. W. Van Someren;Guido A. van Wingen;Henry Völzke;Esther Walton;Lei Wang;Anderson M. Winkler;Katharina Wittfeld;Margaret J. Wright;Je-Yeon Yun;Guohao Zhang;Yanli Zhang-James;Bhim M. Adhikari;Ingrid Agartz;Moji Aghajani;André Aleman;Robert R. Althoff;Andre Altmann;Ole A. Andreassen;David A. Baron;Brenda L. Bartnik-Olson;Janna Marie Bas-Hoogendam;Arielle R. Baskin-Sommers;Carrie E. Bearden;Laura A. Berner;Premika S. W. Boedhoe;Rachel M. Brouwer;Jan K. Buitelaar;Karen Caeyenberghs;Charlotte A. M. Cecil;Ronald A. Cohen;James H. Cole;Patricia J. Conrod;Stephane A. De Brito;Sonja M. C. de Zwarte;Emily L. Dennis;Sylvane Desrivieres;Danai Dima;Stefan Ehrlich;Carrie Esopenko;Graeme Fairchild;Simon E. Fisher;Jean-Paul Fouche;Clyde Francks;Sophia Frangou;Barbara Franke;Hugh P. Garavan;David C. Glahn;Nynke A. Groenewold;Tiril P. Gurholt;Boris A. Gutman;Tim Hahn;Ian H. Harding;Dennis Hernaus;Derrek P. Hibar;Frank G. Hillary;Martine Hoogman;Hilleke E. Hulshoff Pol;Maria Jalbrzikowski;George A. Karkashadze;Eduard T. Klapwijk;Rebecca C. Knickmeyer;Peter Kochunov;Inga K. Koerte;Xiang-Zhen Kong;Sook-Lei Liew;Alexander P. Lin;Mark W. Logue;Eileen Luders;Fabio Macciardi;Scott Mackey;Andrew R. Mayer;Carrie R. McDonald;Agnes B. McMahon;Sarah E. Medland;Gemma Modinos;Rajendra A. Morey;Sven C. Mueller;Pratik Mukherjee;Leyla Namazova-Baranova;Talia M. Nir;Alexander Olsen;Peristera Paschou;Daniel S. Pine;Fabrizio Pizzagalli;Miguel E. Rentería;Jonathan D. Rohrer;Philipp G. Sämann;Lianne Schmaal;Gunter Schumann;Mark S. Shiroishi;Sanjay M. Sisodiya;Dirk J. A. Smit;Ida E. Sønderby;Dan J. Stein;Jason L. Stein;Masoud Tahmasian;David F. Tate;Jessica A. Turner;Odile A. van den Heuvel;Nic J. A. van der Wee;Ysbrand D. van der Werf;Theo G. M. van Erp;Neeltje E. M. van Haren;Daan van Rooij;Laura S. van Velzen;Ilya M. Veer;Dick J. Veltman;Julio E. Villalon-Reina;Henrik Walter;Christopher D. Whelan;Elisabeth A. Wilde;Mojtaba Zarei;Vladimir Zelman - 通讯作者:
Vladimir Zelman
Laura A. Berner的其他文献
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{{ truncateString('Laura A. Berner', 18)}}的其他基金
Dynamic Neural Computations Underlying Cognitive Control in Bulimia Nervosa
神经性贪食症认知控制下的动态神经计算
- 批准号:
10638708 - 财政年份:2023
- 资助金额:
$ 25.35万 - 项目类别:
The Influences of Eating and Fasting on Inhibitory Control in Bulimia Nervosa: A Computational Neuroimaging Study
饮食和禁食对神经性贪食症抑制控制的影响:一项计算神经影像学研究
- 批准号:
10208679 - 财政年份:2019
- 资助金额:
$ 25.35万 - 项目类别:
The Influences of Eating and Fasting on Inhibitory Control in Bulimia Nervosa: A Computational Neuroimaging Study
饮食和禁食对神经性贪食症抑制控制的影响:一项计算神经影像学研究
- 批准号:
9982435 - 财政年份:2019
- 资助金额:
$ 25.35万 - 项目类别:
The Influences of Eating and Fasting on Inhibitory Control in Bulimia Nervosa: A Computational Neuroimaging Study
饮食和禁食对神经性贪食症抑制控制的影响:一项计算神经影像学研究
- 批准号:
10661558 - 财政年份:2019
- 资助金额:
$ 25.35万 - 项目类别:
The Influences of Eating and Fasting on Inhibitory Control in Bulimia Nervosa: A Computational Neuroimaging Study
饮食和禁食对神经性贪食症抑制控制的影响:一项计算神经影像学研究
- 批准号:
10447689 - 财政年份:2019
- 资助金额:
$ 25.35万 - 项目类别:
The Influences of Eating and Fasting on Inhibitory Control in Bulimia Nervosa: A Computational Neuroimaging Study
饮食和禁食对神经性贪食症抑制控制的影响:一项计算神经影像学研究
- 批准号:
10670035 - 财政年份:2019
- 资助金额:
$ 25.35万 - 项目类别:
Neural Bases of Self-regulatory Control in Bulimia Nervosa
神经性贪食症自我调节控制的神经基础
- 批准号:
9392278 - 财政年份:2016
- 资助金额:
$ 25.35万 - 项目类别:
Self-regulatory Control and Eating: A Neuroimaging Study of Bulimia Nervosa
自我调节控制和饮食:神经性贪食症的神经影像学研究
- 批准号:
8457572 - 财政年份:2012
- 资助金额:
$ 25.35万 - 项目类别:
Self-regulatory Control and Eating: A Neuroimaging Study of Bulimia Nervosa
自我调节控制和饮食:神经性贪食症的神经影像学研究
- 批准号:
8544829 - 财政年份:2012
- 资助金额:
$ 25.35万 - 项目类别:
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