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Dissecting the signalling functions of polycomb-mediated ubiquitylation in DNA double-strand break repair

Dissecting the signalling functions of polycomb-mediated ubiquitylation in DNA double-strand break repair
剖析多梳介导的泛素化在 DNA 双链断裂修复中的信号传导功能
批准号:
239080
负责人:
Hendzel Michael J
金额:
$56.0万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2011
资助国家:
加拿大
项目状态:
已结题
起止时间:
2011-09-01 至 2016-09-01

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The presence of stem cells within human tumours and their increased resistance to therapies are thought to be a major reason why some patients fail therapy. We have found that a group of proteins that are essential for maintaining stem cells are also inv
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Canada Research Chair - Tier 1
  • 批准号:
    454008
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2021
  • 负责人:
    Hendzel Michael J
  • 依托单位:
Structure-function relationships at DNA double-strand break repair centers
  • 批准号:
    389213
  • 项目类别:
    Operating Grants
  • 资助金额:
    $61.02万
  • 财政年份:
    2018
  • 负责人:
    Hendzel Michael J
  • 依托单位:
Studying the role of DNA damage induced RNA in the molecular mechanisms promoting homologous recombination in mammalian cells
  • 批准号:
    345110
  • 项目类别:
    Operating Grants
  • 资助金额:
    $54.58万
  • 财政年份:
    2016
  • 负责人:
    Hendzel Michael J
  • 依托单位:
海外基金