Relationship between denervation, mitochondrial dysfunction, and muscle atrophy in sarcopenia

肌少症的去神经支配、线粒体功能障碍和肌肉萎缩之间的关系

• 批准号: 238837
• 负责人: Hepple Russell T
• 金额: $ 43.21万
• 依托单位: Research Institute of the McGill University Health Centre
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-09-01 至 2016-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=238837&lang=en
• 关键词: Aging; Immunofluorescence Microscopy; Mitochondrial Function; Motor Neuron; Neuromuscular Junction; Permeability Transition Pore; Reactive Oxygen Species; Respirometry; Sarcopenia

The causes of the age-related loss of muscle mass and function known as sarcopenia are unknown. Amongst the most frequently implicated culprits is an intrinsic defect in mitochondrial function, an idea supported by the up-regulation of mitochondrial-drive

与年龄相关的肌肉质量和功能损失的原因被称为肌肉减少症是未知的。其中最常见的罪魁祸首是线粒体功能的内在缺陷，这一观点得到了线粒体驱动上调的支持。