Towards antibiotic-free feeding programs for piglets: The role of dietary nucleotides

实现仔猪无抗生素喂养计划：日粮核苷酸的作用

• 批准号: 411218-2010
• 负责人: Nyachoti, Charles
• 金额: $ 3.28万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=490438
• 关键词: Towards; antibiotic; free; feeding; programs

Post-weaning diarrhea in piglets is a major cause of productive and economic losses to the swine industry. Traditionally, the swine industry has managed this disease by utilizing starter diets containing highly digestible and specialized ingredients such as spray dried porcine plasma and sub-therapeutic levels of antibiotics as growth promoters. However, there is intense public pressure to discontinue the use of animal products and antibiotics in pig diets for fear that these products represents a risk to human health. Many of the products that have been tested as alternative antimicrobial growth promoters have not been fully accepted by the swine industry. This may be due to the fact that many of these products such as high levels of zinc oxide and organic acids have problems of their own. Consequently, there is a need for identifying natural alternatives that are not only effective but that are also safe, cost effective, and pose minimal environmental risks. Research will be conducted to explore the potential of a newly developed nucleotide-rich yeast extracts (NRYE) to modulate intestinal development, microbial communities, and immune response in weaned piglets. The use of enzyme supplementation to release carbohydrate components from the yeast culture product which may confer protective benefits to the piglet will be examined. The potential for synergistic interactions between NRYE and supplemental enzymes will be studied with a view of identifying a combination of effective therapies for prevention of piglet diarrhea. A disease challenge model will be used to effectively test the potential antimicrobial capabilities of these products. Results of the project will be useful in developing strategies for sustainable nutritional management options for weaned pigs.

仔猪断奶后腹泻是养猪业生产和经济损失的主要原因。传统上，养猪业通过使用含有高度可消化和专门成分的起始饲料来管理这种疾病，例如喷雾干燥的猪血浆和亚治疗水平的抗生素作为生长促进剂。然而，公众强烈要求停止在猪饲料中使用动物产品和抗生素，因为担心这些产品对人类健康构成风险。许多已被测试为替代抗菌生长促进剂的产品尚未被养猪业完全接受。这可能是由于许多这些产品，如高含量的氧化锌和有机酸本身就有问题。因此，有必要确定不仅有效而且安全、成本效益高、环境风险最小的天然替代品。本研究旨在探索一种新开发的富含核苷酸的酵母提取物（NRYE）对断奶仔猪肠道发育、微生物群落和免疫反应的调节潜力。将研究使用酶补充剂从酵母培养物产品中释放碳水化合物组分，这可能会对仔猪产生保护作用。将研究NRYE和补充酶之间协同相互作用的潜力，以确定预防仔猪腹泻的有效治疗组合。疾病挑战模型将用于有效测试这些产品的潜在抗菌能力。该项目的结果将有助于制定断奶仔猪可持续营养管理方案的战略。