Evaluation of Red Osier Dogwoods' crude extracts immune promoting activity in weaned pigs

红柳山茱萸粗提物对断奶仔猪免疫促进作用的评价

• 批准号: 486316-2015
• 负责人: Nyachoti, Charles
• 金额: $ 1.82万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=585517
• 关键词: Evaluation; Red; Osier; Dogwoods; crude

Post-weaning diarrhea is a major cause of productive and economic losses in swine industry. The sub-therapeutic doses of antibiotics in piglets' diets have effectively minimized the problem and functioned as growth promoters. At a time where antibiotics usage in pigs' diets is gradually being phased out, the adoption of natural remedies such as plant's phenolics could be advantageous to swine producers. The Red Osier Dogwood (Cornus sericea also known as Cornus stolonifera) plant is native to Canada. Depending on the season the total phenolics concentration in the leaves is between 40 to 220 mg/g. This project shall examine the health promoting effect of Red Osier Dogwood's ground leaves and bark on weaned pig and especially on incidence of diarrhea caused by Escherichia coli. A disease challenge model will be used comparing Red Osier Dogwood with commonly used antibiotics on controlling diarrhea in weaned pigs. The results will be beneficial in development of non-antibiotic strategies of dealing with post-weaning diarrhea in piglets. Also, the findings will enable Red Dog Enterprises Limited to market their product as an alternative to dietary antibiotics in piglets.

断奶后腹泻是养猪业生产和经济损失的主要原因。这个 在仔猪日粮中添加亚治疗量的抗生素有效地将问题降至最低，并起到了 生长促进剂。在猪日粮中抗生素的使用逐渐被淘汰的时候，采用 一些天然药物，如植物酚类物质，可能对养猪户有利。红色奥西尔 山茱萸(Cornus Sericea)植物原产于加拿大。取决于 季节，叶片中的总酚浓度在40到220毫克/克之间。本项目将检查 红豆杉磨碎叶和树皮对断奶仔猪的健康促进作用 大肠埃希菌引起的腹泻发病率。一个疾病挑战模型将被用来比较Red Osier 山茱萸配合常用抗生素控制断奶仔猪腹泻。结果将是 有益于开发处理仔猪断奶后腹泻的非抗生素策略。另外， 这一发现将使红狗企业有限公司能够将他们的产品作为饮食的替代品进行营销 仔猪体内的抗生素。